PMID- 31940165
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20201102
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 12
IP  - 5
DP  - 2020 Feb 5
TI  - Biocompatible, Crystalline, and Amorphous Bismuth-Based Metal-Organic Frameworks 
      for Drug Delivery.
PG  - 5633-5641
LID - 10.1021/acsami.9b21692 [doi]
AB  - The synthetic flexibility of metal-organic frameworks (MOFs) with high loading 
      capacities and biocompatibility makes them ideal candidates as drug delivery 
      systems (DDSs). Here, we report the use of CAU-7, a biocompatible bismuth-based 
      MOF, for the delivery of two cancer drugs, sodium dichloroacetate (DCA) and 
      alpha-cyano-4-hydroxycinnamic acid (alpha-CHC). We achieved loadings of 33 and 9 wt % for 
      DCA and alpha-CHC, respectively. Interestingly, CAU-7 showed a gradual release of the 
      drugs, achieving a release time of up to 17 days for DCA and 31 days for alpha-CHC. 
      We then performed mechanical and thermal amorphization processes to attempt to 
      delay the delivery of guest molecules even more. With the thermal treatment, we 
      were able to achieve an outstanding 32% slower release of alpha-CHC from the 
      thermally treated CAU-7. Using in vitro studies and endocytosis inhibitors, 
      confocal microscopy, and fluorescence-activated cell sorting, we also 
      demonstrated that CAU-7 was successfully internalized by cancer cells, partially 
      avoiding lysosome degradation. Finally, we showed that CAU-7 loaded either with 
      DCA or alpha-CHC had a higher therapeutic efficiency compared with the free drug 
      approach, making CAU-7 a great option for biomedical application.
FAU - Orellana-Tavra, Claudia
AU  - Orellana-Tavra C
AD  - Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical 
      Engineering & Biotechnology , University of Cambridge , Philippa Fawcett Drive , 
      Cambridge CB3 0AS , U.K.
FAU - Koppen, Milan
AU  - Koppen M
AD  - Institut fur Anorganische Chemie , Max-Eyth-Strasse 2 , Kiel D-24118 , Germany.
FAU - Li, Aurelia
AU  - Li A
AD  - Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical 
      Engineering & Biotechnology , University of Cambridge , Philippa Fawcett Drive , 
      Cambridge CB3 0AS , U.K.
FAU - Stock, Norbert
AU  - Stock N
AUID- ORCID: 0000-0002-0339-7352
AD  - Institut fur Anorganische Chemie , Max-Eyth-Strasse 2 , Kiel D-24118 , Germany.
FAU - Fairen-Jimenez, David
AU  - Fairen-Jimenez D
AUID- ORCID: 0000-0002-5013-1194
AD  - Adsorption & Advanced Materials Laboratory (A2ML), Department of Chemical 
      Engineering & Biotechnology , University of Cambridge , Philippa Fawcett Drive , 
      Cambridge CB3 0AS , U.K.
LA  - eng
PT  - Journal Article
DEP - 20200124
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Metal-Organic Frameworks)
RN  - U015TT5I8H (Bismuth)
SB  - IM
MH  - Antineoplastic Agents/*chemistry/toxicity
MH  - Bismuth/*chemistry/toxicity
MH  - Cell Survival/drug effects
MH  - Delayed-Action Preparations
MH  - Drug Delivery Systems/*methods
MH  - Drug Stability
MH  - HeLa Cells
MH  - Humans
MH  - Metal-Organic Frameworks/*chemistry/toxicity
OTO - NOTNLM
OT  - MOFs
OT  - cancer
OT  - controlled release
OT  - drug delivery
OT  - endocytosis
EDAT- 2020/01/16 06:00
MHDA- 2020/11/03 06:00
CRDT- 2020/01/16 06:00
PHST- 2020/01/16 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2020/01/16 06:00 [entrez]
AID - 10.1021/acsami.9b21692 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2020 Feb 5;12(5):5633-5641. doi: 
      10.1021/acsami.9b21692. Epub 2020 Jan 24.