PMID- 31941025
OWN - NLM
STAT- MEDLINE
DCOM- 20200930
LR  - 20200930
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 21
IP  - 2
DP  - 2020 Jan 13
TI  - Crosstalk between NLRP12 and JNK during Hepatocellular Carcinoma.
LID - 10.3390/ijms21020496 [doi]
LID - 496
AB  - Hepatocellular carcinoma (HCC), a leading cause of cancer-related death, is 
      initiated and promoted by chronic inflammation. Inflammatory mediators are 
      transcriptionally regulated by several inflammatory signaling pathways, including 
      nuclear factor kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK). cJun 
      N-terminal kinase (JNK), a member of the MAPK family, plays a central role in HCC 
      pathogenesis. Pathogen-associated molecular patterns (PAMPs) activate JNK and 
      other MAPK upon recognition by toll-like receptors (TLRs). Apart from TLRs, PAMPs 
      are sensed by several other pattern recognition receptors, including cytosolic 
      NOD-like receptors (NLRs). In a recent study, we demonstrated that the NLR member 
      NLRP12 plays a critical role in suppressing HCC via negative regulation of the 
      JNK pathway. This article briefly reviews the crosstalk between NLRP12 and JNK 
      that occurs during HCC.
FAU - Khan, Shahanshah
AU  - Khan S
AUID- ORCID: 0000-0003-3052-932X
AD  - Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
FAU - Zaki, Hasan
AU  - Zaki H
AUID- ORCID: 0000-0001-9002-5399
AD  - Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
LA  - eng
GR  - RP160169/Cancer Prevention and Research Institute of Texas (CPRIT)/
PT  - Journal Article
PT  - Review
DEP - 20200113
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NLRP12 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - EC 2.7.12.2 (MAP Kinase Kinase 4)
SB  - IM
MH  - Carcinoma, Hepatocellular/*metabolism/pathology
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*metabolism
MH  - Liver Neoplasms/*metabolism/pathology
MH  - MAP Kinase Kinase 4/*metabolism
MH  - *MAP Kinase Signaling System
MH  - Neoplasm Proteins/*metabolism
PMC - PMC7013925
OTO - NOTNLM
OT  - JNK
OT  - NLRP12
OT  - hepatocellular carcinoma
OT  - inflammation
COIS- Authors declared no conflict of interest to disclose.
EDAT- 2020/01/17 06:00
MHDA- 2020/10/02 06:00
PMCR- 2020/01/01
CRDT- 2020/01/17 06:00
PHST- 2019/12/19 00:00 [received]
PHST- 2019/12/31 00:00 [revised]
PHST- 2020/01/08 00:00 [accepted]
PHST- 2020/01/17 06:00 [entrez]
PHST- 2020/01/17 06:00 [pubmed]
PHST- 2020/10/02 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ijms21020496 [pii]
AID - ijms-21-00496 [pii]
AID - 10.3390/ijms21020496 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Jan 13;21(2):496. doi: 10.3390/ijms21020496.