PMID- 31941189
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200116
IS  - 1098-2345 (Electronic)
IS  - 0275-2565 (Linking)
VI  - 29
IP  - 3
DP  - 1993
TI  - Hematologic reference values for the fetal long-tailed macaque (Macaca 
      fascicularis).
PG  - 209-219
LID - 10.1002/ajp.1350290306 [doi]
AB  - Complete blood counts (CBCs) were performed on 68 fetal macaque blood samples 
      collected from 31 fetuses by repeat ultrasound-guided cardiocentesis (gestational 
      day [GD] 80-150; term  approximately  GD 165) with the goal of defining normative hematologic 
      reference values during prenatal life. Lymphocytes were the primary white blood 
      cells (WBCs) observed throughout gestation. Segmented neutrophils were the second 
      highest percent of WBCs and were noted to rise significantly during GD 130-140. 
      Overall, WBCs increased progressively throughout gestation with a transient 
      decline at the beginning of the third trimester ( approximately  GD 110). A steady linear rise 
      in red blood cells (RBCs), hemoglobin, and hematocrit was observed with a 
      marginal decline close to term; mean corpuscular hemoglobin (MCH) and mean 
      corpuscular volume (MCV) showed a consistent linear decline throughout gestation 
      whereas mean corpuscular hemoglobin concentration (MCHC) remained relatively 
      stable. Nucleated RBCs (NRBCs per 100 WBCs) were present on GD 80, showed a sharp 
      decline mid-second trimester ( approximately  GD 90), and were significantly diminished by the 
      beginning of the third trimester ( approximately  GD 110). No quantitative changes in platelets 
      were noted throughout the study period. Evaluations of erythrocyte morphology 
      indicated polychromasia and anisocytosis as typical characteristics throughout 
      gestation with rare occurrence of hypochromasia and poikilocytosis. Howell-Jolly 
      bodies were intermittently observed. These data reveal distinct similarities when 
      compared to prenatal hematologic characteristics for human fetuses and provide 
      baseline data which can be applied to experimental studies where prenatal 
      hematopoietic/hematologic toxicity may be anticipated. (c) 1993 Wiley-Liss, Inc.
CI  - Copyright (c) 1993 Wiley-Liss, Inc., A Wiley Company.
FAU - Tarantal, Alice F
AU  - Tarantal AF
AD  - California Regional Primate Research Center, University of California, Davis, 
      California.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Primatol
JT  - American journal of primatology
JID - 8108949
SB  - IM
OTO - NOTNLM
OT  - M. fascicularis
OT  - cardiocentesis
OT  - fetal blood
OT  - hematopoiesis
OT  - ultrasonography
EDAT- 1993/01/01 00:00
MHDA- 1993/01/01 00:01
CRDT- 2020/01/17 06:00
PHST- 1992/06/15 00:00 [received]
PHST- 1992/10/18 00:00 [revised]
PHST- 2020/01/17 06:00 [entrez]
PHST- 1993/01/01 00:00 [pubmed]
PHST- 1993/01/01 00:01 [medline]
AID - 10.1002/ajp.1350290306 [doi]
PST - ppublish
SO  - Am J Primatol. 1993;29(3):209-219. doi: 10.1002/ajp.1350290306.