PMID- 31941282
OWN - NLM
STAT- MEDLINE
DCOM- 20210412
LR  - 20210412
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 36
IP  - 5
DP  - 2020 Feb 11
TI  - Host-Guest Interactions between Oxaliplatin and Cucurbit[7]uril/Cucurbit[7]uril 
      Derivatives under Pseudo-Physiological Conditions.
PG  - 1235-1240
LID - 10.1021/acs.langmuir.9b03325 [doi]
AB  - Compared with conventional drug delivery systems (DDSs), DDSs based on host-guest 
      interactions possess unique advantages, such as high selectivity, tunable binding 
      ability, and controllable release of drugs. It is important to study the 
      host-guest interactions between the carrier and drug under physiological 
      conditions for constructing DDSs. In this work, we have studied the host-guest 
      interaction between cucurbit[7]uril (CB[7]) and oxaliplatin (OxPt), a clinical 
      antitumor drug, in the cell culture medium. The results show that amino acids 
      such as phenylalanine in the 1640 culture medium can partially occupy the cavity 
      of CB[7], which leads to the decrease of enthalpy changes of the host-guest 
      interaction between OxPt and CB[7]. In addition, inorganic salts such as NaCl in 
      the medium reduce the enthalpy change and increase the entropy change of the 
      binding because of the preorganization of the portal of CB[7] and sodium cation. 
      As a result, the binding constant of CB[7] with OxPt in the 1640 culture medium 
      is 1/20 of that in pure water. When CB[7] is modified at the terminal of 
      star-type PEG to construct the star-PEGylated CB[7], it is shown that the 
      molecular weight and topological structure of the PEG polymer backbone exhibit 
      little effect on the host-guest interactions between CB[7] and OxPt. This study 
      enriches the host-guest chemistry of cucurbiturils and may provide guidance for 
      constructing novel DDSs based on host-guest interactions with high loading and 
      releasing efficiency.
FAU - Wu, Han
AU  - Wu H
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry , Tsinghua University , Beijing 100084 , China.
FAU - Chen, Hao
AU  - Chen H
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry , Tsinghua University , Beijing 100084 , China.
FAU - Tang, Bohan
AU  - Tang B
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry , Tsinghua University , Beijing 100084 , China.
FAU - Kang, Yuetong
AU  - Kang Y
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry , Tsinghua University , Beijing 100084 , China.
FAU - Xu, Jiang-Fei
AU  - Xu JF
AUID- ORCID: 0000-0001-8181-6113
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry , Tsinghua University , Beijing 100084 , China.
FAU - Zhang, Xi
AU  - Zhang X
AD  - Key Lab of Organic Optoelectronics & Molecular Engineering, Department of 
      Chemistry , Tsinghua University , Beijing 100084 , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200127
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Bridged-Ring Compounds)
RN  - 0 (Drug Carriers)
RN  - 0 (Imidazoles)
RN  - 0 (cucurbit(7)uril)
RN  - 04ZR38536J (Oxaliplatin)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 47E5O17Y3R (Phenylalanine)
RN  - 94ZLA3W45F (Arginine)
SB  - IM
MH  - Antineoplastic Agents/*chemistry
MH  - Arginine/chemistry
MH  - Bridged-Ring Compounds/*chemistry
MH  - Drug Carriers/*chemistry
MH  - Imidazoles/*chemistry
MH  - Oxaliplatin/*chemistry
MH  - Phenylalanine/chemistry
MH  - Sodium Chloride/chemistry
MH  - Thermodynamics
EDAT- 2020/01/17 06:00
MHDA- 2021/04/13 06:00
CRDT- 2020/01/17 06:00
PHST- 2020/01/17 06:00 [pubmed]
PHST- 2021/04/13 06:00 [medline]
PHST- 2020/01/17 06:00 [entrez]
AID - 10.1021/acs.langmuir.9b03325 [doi]
PST - ppublish
SO  - Langmuir. 2020 Feb 11;36(5):1235-1240. doi: 10.1021/acs.langmuir.9b03325. Epub 
      2020 Jan 27.