PMID- 31943095
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1742-3406 (Electronic)
IS  - 0144-8420 (Linking)
VI  - 188
IP  - 4
DP  - 2020 Jul 2
TI  - NOVEL 'PHOTONEUTRON VOLUME DOSE EQUIVALENT' HYPOTHESIS AND METHODOLOGY FOR SECOND 
      PRIMARY CANCER RISK ESTIMATION IN HIGH-ENERGY X-RAY MEDICAL ACCELERATORS.
PG  - 432-443
LID - 10.1093/rpd/ncz303 [doi]
AB  - A novel 'photoneutron (PN) volume dose equivalent' methodology was hypothesized 
      and applied for the first time for estimating PN second primary cancer (PN-SPC) 
      risks in high-energy X-ray medical accelerators. Novel position-sensitive 
      mega-size polycarbonate dosimeters with 10B converter (with or without cadmium 
      covers) were applied for determining fast, epithermal and thermal PN dose 
      equivalents at positions on phantom surface and depths. The methodology was 
      applied to sites of tumors such as brain, stomach and prostate in 47 patients. 
      The PN-SPC risks were estimated for specific organs/tissues using linear 
      International Commission on Radiological Protection cancer risks and were 
      compared with some available data. The corresponding PN-SPC risk estimates ranged 
      from 1.450 x 10-3 to 1.901 cases per 10 000 persons per Gray. The method was 
      applied to 47 patients for estimating PN-SPC risks in patients undergoing 
      radiotherapy. The PN-SPC risk estimates well match those calculated by simulation 
      but are comparatively different from those estimated by 'PN point dose 
      equivalent' methods, as expected.
CI  - (c) The Author(s) 2020. Published by Oxford University Press. All rights reserved. 
      For Permissions, please email: journals.permissions@oup.com.
FAU - Sohrabi, Mehdi
AU  - Sohrabi M
AD  - Health Physics and Dosimetry Research Laboratory, Department of Energy 
      Engineering and Physics, Amirkabir University of Technology, Tehran, Iran.
FAU - Hakimi, Amir
AU  - Hakimi A
AD  - Health Physics and Dosimetry Research Laboratory, Department of Energy 
      Engineering and Physics, Amirkabir University of Technology, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Radiat Prot Dosimetry
JT  - Radiation protection dosimetry
JID - 8109958
SB  - IM
MH  - Humans
MH  - Male
MH  - *Neoplasms, Second Primary/epidemiology/etiology
MH  - Neutrons
MH  - Particle Accelerators
MH  - Radiometry
MH  - X-Rays
EDAT- 2020/01/17 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/01/17 06:00
PHST- 2019/01/02 00:00 [received]
PHST- 2019/12/04 00:00 [revised]
PHST- 2020/01/03 00:00 [accepted]
PHST- 2020/01/17 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/01/17 06:00 [entrez]
AID - 5704035 [pii]
AID - 10.1093/rpd/ncz303 [doi]
PST - ppublish
SO  - Radiat Prot Dosimetry. 2020 Jul 2;188(4):432-443. doi: 10.1093/rpd/ncz303.