PMID- 31943805
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230113
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 98
IP  - 5
DP  - 2020 Aug
TI  - Pupillary light responses in type 1 and type 2 diabetics with and without 
      retinopathy.
PG  - 477-484
LID - 10.1111/aos.14348 [doi]
AB  - OBJECTIVE: We assessed the function of rod/cones and melanopsin in type 1 (T1DM) 
      and type 2 diabetes mellitus (T2DM) with and without non-proliferative diabetic 
      retinopathy (NPDR). METHODS: We performed pupillometry on 22 healthy controls and 
      four diabetic groups: 12 T1DM patients without NPDR and 12 with moderate NPDR, 
      and 16 T2DM patients without NPDR and 12 with moderate NPDR. Monocular 
      stimulations of 20 seconds with red (lambda = 633 nm) and blue light (lambda = 463 nm) at 
      ~15 log quanta/cm(2) /second were performed. The primary outcome was the 
      melanopsin-mediated late redilation phase of postillumination pupillary light 
      response (PIPR(L) (ate) ) to blue light. The secondary outcomes were the mixed 
      rod/cone and melanopsin responses, that is maximal pupil constriction and the 
      early redilation phase of PIPR (PIPR(E) (arly) ). RESULTS: Late redilation phase 
      of PIPR (PIPR(L) (ate) ) to blue and red light stimuli was not significantly 
      different between healthy control and the four diabetic groups (n.s.). The 
      maximal pupil contractions to blue light stimulus were significantly reduced in 
      T1DM patients as well as in T2DM patients with NPDR (p </= 0.02), whereas for red 
      light stimuli, the maximal pupil constriction was only reduced in T2DM with NPDR 
      (p < 0.01). Early redilation phase of PIPR (PIPR(E) (arly) ) to blue and red 
      light stimuli was not significantly different between healthy controls and 
      diabetic patients (n.s.). CONCLUSION: Neither the PIPR(E) (arly) nor the PIPR(L) 
      (ate) was significantly reduced in diabetics with or without NPDR compared to 
      healthy controls. The reduced maximal pupil constrictions in diabetics with NPDR 
      indicate decreased mixed rod/cone and melanopsin responses.
CI  - (c) 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & 
      Sons Ltd.
FAU - Ba-Ali, Shakoor
AU  - Ba-Ali S
AUID- ORCID: 0000-0001-8799-2775
AD  - Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Brondsted, Adam Elias
AU  - Brondsted AE
AD  - Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
FAU - Andersen, Henrik Ullits
AU  - Andersen HU
AD  - Steno Diabetes Centre, Gentofte, Denmark.
FAU - Jennum, Poul
AU  - Jennum P
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
AD  - Danish Centre for Sleep Medicine, Neurophysiology Clinic, Rigshospitalet, 
      Glostrup, Denmark.
FAU - Lund-Andersen, Henrik
AU  - Lund-Andersen H
AD  - Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
AD  - Steno Diabetes Centre, Gentofte, Denmark.
LA  - eng
PT  - Journal Article
DEP - 20200113
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
OTO - NOTNLM
OT  - cone
OT  - diabetic retinopathy
OT  - ipRGCs
OT  - melanopsin
OT  - pupillary light reflex
OT  - pupillometry
EDAT- 2020/01/17 06:00
MHDA- 2020/01/17 06:01
CRDT- 2020/01/17 06:00
PHST- 2018/08/17 00:00 [received]
PHST- 2019/12/20 00:00 [accepted]
PHST- 2020/01/17 06:00 [pubmed]
PHST- 2020/01/17 06:01 [medline]
PHST- 2020/01/17 06:00 [entrez]
AID - 10.1111/aos.14348 [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2020 Aug;98(5):477-484. doi: 10.1111/aos.14348. Epub 2020 Jan 
      13.