PMID- 31944588
OWN - NLM
STAT- MEDLINE
DCOM- 20201216
LR  - 20201216
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 23
IP  - 2
DP  - 2020 Feb
TI  - Contribution of HLA-B*51:01 and -A*26:01 to Behcet's disease and their clinical 
      association in Thai patients.
PG  - 247-255
LID - 10.1111/1756-185X.13785 [doi]
AB  - AIMS: To investigate susceptible human leukocyte antigen (HLA) alleles and their 
      associations with clinical features in Thai patients with Behcet's disease (BD). 
      METHOD: Eighteen HLA-A and 36 HLA-B alleles were determined in 42 Thai BD 
      patients and 99 healthy controls (HCs) by reverse line blot assay, and 
      reconfirmed by MICRO SSP assay. RESULTS: The BD patients had significantly higher 
      allele frequency (AF) of HLA-B*51 than the HCs (13.10% vs 5.05%, P = .025). The 
      AF of HLA-A*26, -A*26:01 and -B*51:01 also was higher and almost reached 
      statistical significance (5.59% vs 1.52%, P = .054, 5.95% vs 1.52%, P = .054 and 
      10.71% vs 4.04%, P = .051, respectively). However, the BD patients had 
      significantly higher AF of either HLA-A*26:01 or -B*51:01 (16.67% vs 5.56%, 
      P = .005), or -A*26:01 or -B*51X (19.05% vs 6.56%, P = .003). The AF of 
      HLA-B*51:01 and -B*51X increased significantly in -A*26:01 non-carrier BD 
      patients (12.16% vs 4.17%, P = .024 and 14.86% vs 5.21%, P = .019, respectively); 
      and that of HLA-A*26:01 was significantly higher in -B*51X non-carrier BD 
      patients (7.58% vs 1.67%, P = .034). HLA-B*51:01 associated significantly with 
      the presence of posterior uveitis and visual impairment (18.18% vs 2.50%, 
      P = .031 for both conditions). HLA-B*51:01 was not observed in BD patients with 
      gastrointestinal involvement or arthritis. Furthermore, the AF of HLA-B*51:01 was 
      significantly higher in HLA-A*26:01 non-carrier BD patients without arthritis 
      (17.30% vs 0%, P = .050). CONCLUSION: HLA-B*51:01 was a susceptible allele for 
      Thai BD patients, and associated with posterior uveitis and visual impairment. 
      HLA-A*26:01 was another susceptible allele in HLA-B*51X non-carrier patients. The 
      protective effect of HLA-B*51:01 on arthritis needs further investigation.
CI  - (c) 2020 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Louthrenoo, Worawit
AU  - Louthrenoo W
AUID- ORCID: 0000-0003-3105-6122
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
FAU - Kasitanon, Nuntana
AU  - Kasitanon N
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
FAU - Pathanapitoon, Kessara
AU  - Pathanapitoon K
AD  - Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang 
      Mai, Thailand.
FAU - Wangkaew, Suparaporn
AU  - Wangkaew S
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
FAU - Kuwata, Shoji
AU  - Kuwata S
AD  - Department of Internal Medicine, Faculty of Medicine, Teikyo University School of 
      Medicine, Ichihara, Japan.
FAU - Nishi, Ai
AU  - Nishi A
AD  - Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan.
FAU - Kaburaki, Toshikatsu
AU  - Kaburaki T
AD  - Department of Ophthalmology, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Tanaka, Rie
AU  - Tanaka R
AD  - Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan.
FAU - Takeuchi, Fujio
AU  - Takeuchi F
AD  - Department of Internal Medicine (Allergy and Rheumatology), Faculty of Medicine, 
      University of Tokyo, Tokyo, Japan.
LA  - eng
GR  - No. 01-2004/Chiang Mai University Research Fund/
GR  - No. 23406031, and No. 16H05840/Grants-in-Aid for Science Research from the 
      Ministry of Education, Culture, Sport, Science and Technology of Japan/
PT  - Journal Article
DEP - 20200115
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*26 antigen)
RN  - 0 (HLA-B51 Antigen)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Behcet Syndrome/epidemiology/*immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - HLA-A Antigens/genetics/*immunology
MH  - HLA-B51 Antigen/genetics/*immunology
MH  - Humans
MH  - Immunoblotting
MH  - Incidence
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Thailand/epidemiology
OTO - NOTNLM
OT  - Behcet's disease
OT  - HLA
OT  - MHC class I
OT  - genetic susceptibility
EDAT- 2020/01/17 06:00
MHDA- 2020/12/17 06:00
CRDT- 2020/01/17 06:00
PHST- 2019/10/23 00:00 [received]
PHST- 2019/11/30 00:00 [revised]
PHST- 2019/12/16 00:00 [accepted]
PHST- 2020/01/17 06:00 [pubmed]
PHST- 2020/12/17 06:00 [medline]
PHST- 2020/01/17 06:00 [entrez]
AID - 10.1111/1756-185X.13785 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2020 Feb;23(2):247-255. doi: 10.1111/1756-185X.13785. Epub 2020 
      Jan 15.