PMID- 31945535 OWN - NLM STAT- MEDLINE DCOM- 20200406 LR - 20200408 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 712 DP - 2020 Apr 10 TI - Selected essential trace elements in maternal serum and risk for fetal orofacial clefts. PG - 136542 LID - S0048-9697(20)30052-8 [pii] LID - 10.1016/j.scitotenv.2020.136542 [doi] AB - BACKGROUND: Disturbances in the homeostasis of essential trace elements (ETEs) may interfere with embryonic organogenesis. However, the effect of ETEs on the development of orofacial clefts (OFCs) remains unclear. OBJECTIVES: This study examined associations between concentrations of iron (Fe), zinc (Zn), selenium (Se), cuprum (Cu), cobalt (Co), and molybdenum (Mo) in maternal serum and risk for OFCs in offspring. METHODS: A total of 130 cases of OFCs and 260 nonmalformed controls were included in this study. Concentrations of Fe, Zn, Se, Cu, Co, and Mo in maternal serum were detected by inductively coupled plasma mass spectrometry. We examined associations between levels of the six ETEs in maternal serum and risk for OFCs for each element separately using multilevel mixed-effects logistic regression and for all elements collectively using Bayesian kernel machine regression (BKMR). RESULTS: Higher concentrations of Mo and Co in maternal serum were associated with a decreased risk for OFCs in a dose-dependent manner, with odds ratios and 95% confidence intervals of 0.37 (0.20-0.66) for the second tertile of Mo, 0.28 (0.15-0.54) for the third tertile of Mo, 0.54 (0.29-1.00) for the second tertile of Co, and 0.47 (0.25-0.87) for the third tertile of Co, with the lowest tertile as the referent. When all six ETEs were considered together, increased levels of ETEs were associated with a decreased risk for OFCs. In addition, Mo showed a protective effect against risk for OFCs when the other ETEs were fixed at their 25th, 50th, or 75th percentile, whereas the protective effect of Co turned to a null effect in the BKMR model. No association was observed between levels of Fe, Zn, Se, or Cu and risk for OFCs in either statistical model. CONCLUSION: Elevated concentrations of Mo in maternal serum were associated with a reduced risk for OFCs. CI - Copyright (c) 2020. Published by Elsevier B.V. FAU - Yin, Shengju AU - Yin S AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100191, China. FAU - Wang, Chengrong AU - Wang C AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Beijing Obstetrics and Genecology Hospital, Capital Medical University, Beijing 100026, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wei, Jing AU - Wei J AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Liu, Jufen AU - Liu J AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Linlin AU - Wang L AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Li, Zhiwen AU - Li Z AD - Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing 100191, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Yin, Chenghong AU - Yin C AD - Beijing Obstetrics and Genecology Hospital, Capital Medical University, Beijing 100026, China. Electronic address: yinchh@ccmu.edu.cn. FAU - Ren, Aiguo AU - Ren A AD - Beijing Obstetrics and Genecology Hospital, Capital Medical University, Beijing 100026, China; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. Electronic address: renag@bjmu.edu.cn. LA - eng PT - Journal Article DEP - 20200107 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Trace Elements) RN - H6241UJ22B (Selenium) SB - IM EIN - Sci Total Environ. 2020 Jun 10;720:137592. PMID: 32192715 MH - Bayes Theorem MH - *Cleft Lip MH - *Cleft Palate MH - Humans MH - Selenium MH - Trace Elements OTO - NOTNLM OT - Essential trace element OT - Maternal serum OT - Molybdenum OT - Orofacial clefts COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/01/17 06:00 MHDA- 2020/04/09 06:00 CRDT- 2020/01/17 06:00 PHST- 2019/11/05 00:00 [received] PHST- 2020/01/03 00:00 [revised] PHST- 2020/01/03 00:00 [accepted] PHST- 2020/01/17 06:00 [pubmed] PHST- 2020/04/09 06:00 [medline] PHST- 2020/01/17 06:00 [entrez] AID - S0048-9697(20)30052-8 [pii] AID - 10.1016/j.scitotenv.2020.136542 [doi] PST - ppublish SO - Sci Total Environ. 2020 Apr 10;712:136542. doi: 10.1016/j.scitotenv.2020.136542. Epub 2020 Jan 7.