PMID- 31945745
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20210111
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 12
IP  - 2
DP  - 2020 Jan 16
TI  - Romo1 is involved in the immune response of glioblastoma by regulating the 
      function of macrophages.
PG  - 1114-1127
LID - 10.18632/aging.102648 [doi]
AB  - Reactive oxygen species (ROS) modulator 1 (Romo1) is a mitochondrial membrane 
      protein that is essential for the regulation of mitochondrial ROS production and 
      redox sensing. Although the physiological functions of Romo1 have been studied 
      for the past few years, the role of Romo1 in cancer remained unclear. In this 
      study, we found that the high expression of Romo1 is associated with the poor 
      prognosis of glioblastoma patients. Further study revealed that Romo1 is highly 
      expressed in macrophages, indicating that the overexpression of Romo1 may 
      participate in the function of macrophages and contribute to the progression of 
      glioblastoma. Through the glioblastoma mouse model, we found that the 
      overexpression of Romo1 in bone marrow cells significantly inhibited the immune 
      response within tumor microenvironment, and that the overexpression of Romo1 
      resulted in the M2 polarization of bone marrow derived macrophages (BMDMs) 
      through mTORC1 signaling pathway. In addition, the inhibition of Romo1 combining 
      with anti-PD-1 immunotherapy significantly improved the survival outcome of 
      glioblastoma in mouse model. Collectively, our study highlights the important 
      role of Romo1 in immune response especially the function of macrophages, and 
      implicates it as a potential target of immunotherapy for glioblastoma.
FAU - Sun, Guan
AU  - Sun G
AD  - Department of Neurosurgery, Yancheng City No.1 People's Hospital, The Fourth 
      Affiliated Hospital of Nantong University, Yancheng, PR China.
FAU - Cao, Ying
AU  - Cao Y
AD  - Department of Ear-Nose-Throat, The Second People's Hospital of Huai'an, Huai'an 
      Affiliated Hospital of Xuzhou Medical University, Huai'an, PR China.
FAU - Qian, Chunfa
AU  - Qian C
AD  - Department of Neurosurgery, The Affiliated Brain Hospital of Nanjing Medical 
      University, Nanjing, PR China.
FAU - Wan, Zhengqiang
AU  - Wan Z
AD  - Department of Neurosurgery, Yancheng City No.1 People's Hospital, The Fourth 
      Affiliated Hospital of Nantong University, Yancheng, PR China.
FAU - Zhu, Jian
AU  - Zhu J
AD  - Department of Neurosurgery, Yancheng City No.1 People's Hospital, The Fourth 
      Affiliated Hospital of Nantong University, Yancheng, PR China.
FAU - Guo, Jun
AU  - Guo J
AD  - Department of Neurosurgery, Yancheng City No.1 People's Hospital, The Fourth 
      Affiliated Hospital of Nantong University, Yancheng, PR China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Neurosurgery, The First People's Hospital of Kunshan Affiliated 
      with Jiangsu University, Suzhou, Jiangsu, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200116
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Membrane Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (ROMO1 protein, human)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Animals
MH  - Cell Line, Tumor
MH  - Disease Susceptibility
MH  - Energy Metabolism
MH  - Glioblastoma/*etiology/*metabolism/pathology/therapy
MH  - Humans
MH  - *Immunity
MH  - Macrophage Activation/genetics/immunology
MH  - Macrophages/*immunology/*metabolism
MH  - Membrane Proteins/genetics/*metabolism
MH  - Mice
MH  - Mitochondrial Proteins/genetics/*metabolism
MH  - Reactive Oxygen Species/metabolism
PMC - PMC7053633
OTO - NOTNLM
OT  - Romo1
OT  - glioblastoma
OT  - immune response
OT  - immunotherapy
OT  - macrophages
COIS- CONFLICTS OF INTEREST: All of the contributing authors declared no conflicts of 
      interest.
EDAT- 2020/01/17 06:00
MHDA- 2021/01/12 06:00
PMCR- 2020/01/31
CRDT- 2020/01/17 06:00
PHST- 2019/08/18 00:00 [received]
PHST- 2019/12/23 00:00 [accepted]
PHST- 2020/01/17 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2020/01/17 06:00 [entrez]
PHST- 2020/01/31 00:00 [pmc-release]
AID - 102648 [pii]
AID - 10.18632/aging.102648 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2020 Jan 16;12(2):1114-1127. doi: 10.18632/aging.102648. Epub 
      2020 Jan 16.