PMID- 31945810
OWN - NLM
STAT- MEDLINE
DCOM- 20200727
LR  - 20200727
IS  - 2095-8137 (Print)
IS  - 2095-8137 (Linking)
VI  - 41
IP  - 2
DP  - 2020 Mar 18
TI  - Co-localization of two-color rAAV2-retro confirms the dispersion characteristics 
      of efferent projections of mitral cells in mouse accessory olfactory bulb.
PG  - 148-156
LID - 2095-8137(2020)02-0148-09 [pii]
LID - 10.24272/j.issn.2095-8137.2020.020 [doi]
AB  - The accessory olfactory bulb (AOB), located at the posterior dorsal aspect of the 
      main olfactory bulb (MOB), is the first brain relay of the accessory olfactory 
      system (AOS), which can parallelly detect and process volatile and nonvolatile 
      social chemosignals and mediate different sexual and social behaviors with the 
      main olfactory system (MOS). However, due to its anatomical location and absence 
      of specific markers, there is a lack of research on the internal and external 
      neural circuits of the AOB. This issue was addressed by single-color labeling and 
      fluorescent double labeling using retrograde rAAVs injected into the bed nucleus 
      of the stria terminalis (BST), anterior cortical amygdalar area (ACo), medial 
      amygdaloid nucleus (MeA), and posteromedial cortical amygdaloid area (PMCo) in 
      mice. We demonstrated the effectiveness of this AOB projection neuron labeling 
      method and showed that the mitral cells of the AOB exhibited efferent projection 
      dispersion characteristics similar to those of the MOB. Moreover, there were 
      significant differences in the number of neurons projected to different brain 
      regions, which indicated that each mitral cell in the AOB could project to a 
      different number of neurons in different cortices. These results provide a 
      circuitry basis to help understand the mechanism by which pheromone information 
      is encoded and decoded in the AOS.
FAU - Zheng, Ning
AU  - Zheng N
AD  - Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic 
      and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key 
      Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of 
      Physics and Mathematics, Innovation Academy for Precision Measurement Science and 
      Technology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
AD  - University of the Chinese Academy of Sciences, Beijing 100049, China.
FAU - Wang, Zhi-Zhong
AU  - Wang ZZ
AD  - Department of Automation, School of Electrical Engineering, Zhengzhou University, 
      Zhengzhou, Henan 450001, China.
FAU - Wang, Song-Wei
AU  - Wang SW
AD  - Department of Automation, School of Electrical Engineering, Zhengzhou University, 
      Zhengzhou, Henan 450001, China.
FAU - Yang, Fang-Jia
AU  - Yang FJ
AD  - School of Life Science, Wuhan University, Wuhan, Hubei 430072, China.
FAU - Zhu, Xu-Tao
AU  - Zhu XT
AD  - Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic 
      and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key 
      Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of 
      Physics and Mathematics, Innovation Academy for Precision Measurement Science and 
      Technology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
FAU - Lu, Chen
AU  - Lu C
AD  - School of Life Science, Wuhan University, Wuhan, Hubei 430072, China.
FAU - Manyande, Anne
AU  - Manyande A
AD  - School of Human and Social Sciences, University of West London, Middlesex TW89GA, 
      UK.
FAU - Rao, Xiao-Ping
AU  - Rao XP
AD  - Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic 
      and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key 
      Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of 
      Physics and Mathematics, Innovation Academy for Precision Measurement Science and 
      Technology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China. E-mail: 
      raoxiaoping0902@wipm.ac.cn.
FAU - Xu, Fu-Qiang
AU  - Xu FQ
AD  - Center of Brain Science, State Key Laboratory of Magnetic Resonance and Atomic 
      and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key 
      Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of 
      Physics and Mathematics, Innovation Academy for Precision Measurement Science and 
      Technology, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
AD  - University of the Chinese Academy of Sciences, Beijing 100049, China.
AD  - Divisions of Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, 
      Wuhan, Hubei 430074, China. E-mail: fuqiang.xu@wipm.ac.cn.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Zool Res
JT  - Zoological research
JID - 101697192
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Efferent Pathways/cytology/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurons
MH  - Olfactory Bulb/cytology/*physiology
MH  - Olfactory Pathways/cytology/*physiology
PMC - PMC7109009
OTO - NOTNLM
OT  - Accessory olfactory bulb
OT  - Circuitry basis
OT  - Dispersion characteristics
OT  - Efferent projections
OT  - Projection neuron labeling
OT  - Retrograde rAAVs
EDAT- 2020/01/17 06:00
MHDA- 2020/07/28 06:00
PMCR- 2020/03/18
CRDT- 2020/01/17 06:00
PHST- 2020/01/17 06:00 [pubmed]
PHST- 2020/07/28 06:00 [medline]
PHST- 2020/01/17 06:00 [entrez]
PHST- 2020/03/18 00:00 [pmc-release]
AID - 2095-8137(2020)02-0148-09 [pii]
AID - zr-41-2-148 [pii]
AID - 10.24272/j.issn.2095-8137.2020.020 [doi]
PST - ppublish
SO  - Zool Res. 2020 Mar 18;41(2):148-156. doi: 10.24272/j.issn.2095-8137.2020.020.