PMID- 31946748
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20240216
IS  - 2694-0604 (Electronic)
IS  - 1557-170X (Print)
IS  - 2375-7477 (Linking)
VI  - 2019
DP  - 2019 Jul
TI  - Functional LGE Imaging: Cardiac Phase-Resolved Assessment of Focal Fibrosis.
PG  - 3999-4003
LID - 10.1109/EMBC.2019.8857759 [doi]
AB  - Cardiac Magnetic Resonance Imaging (CMR) is a central tool for diagnosis of 
      various ischemic and non-ischemic cardiomyopathies. CMR protocols commonly 
      comprise assessment of functional properties using cardiac phase-resolved CINE 
      MRI and characterization of myocardial viability using late gadolinium 
      enhancement (LGE) imaging. Conventional LGE imaging requires inversion recovery 
      preparation with a specific inversion time to null the healthy myocardium, which 
      restricts the acquisition to a single cardiac phase. In turn, this necessitates 
      separate scans for cardiac function and viability. In this work, we develop a new 
      method for functional LGE imaging in a single breath-hold using a three-step 
      approach: 1) ECG-triggered multi-contrast data is acquired for each cardiac 
      phase, 2) semi-quantitative relaxation maps are generated, 3) LGE imaging 
      contrast is synthesized based on the semi-quantitative maps. The proposed 
      functional LGE method is evaluated in four healthy subject and 20 patients at 
      1.5T and 3T. Thorough suppression of the healthy myocardium, as well as 40-80ms 
      temporal resolution are achieved, with no visually apparent temporal blurring at 
      tissue interfaces. Functional LGE in patients with focal scar demonstrates robust 
      hyperenhancement in the scar area throughout all cardiac phases, allowing for 
      visual assessment of scar motility. The proposed technique bears the potential to 
      simplify and speedup common cardiac imaging protocols, while enabling improved 
      data fusion of functional and viability information for improved evaluation of 
      CMR.
FAU - Weingartner, Sebastian
AU  - Weingartner S
FAU - Demirel, Omer Burak
AU  - Demirel OB
FAU - Shenoy, Chetan
AU  - Shenoy C
FAU - Schad, Lothar R
AU  - Schad LR
FAU - Schulz-Menger, Jeanette
AU  - Schulz-Menger J
FAU - Akcakaya, Mehmet
AU  - Akcakaya M
LA  - eng
GR  - P41 EB015894/EB/NIBIB NIH HHS/United States
GR  - P41 EB027061/EB/NIBIB NIH HHS/United States
GR  - R00 HL111410/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - *Contrast Media
MH  - Fibrosis
MH  - *Gadolinium
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Myocardium
MH  - Predictive Value of Tests
PMC - PMC6986779
MID - NIHMS1064590
EDAT- 2020/01/18 06:00
MHDA- 2020/04/21 06:00
PMCR- 2020/07/01
CRDT- 2020/01/18 06:00
PHST- 2020/01/18 06:00 [entrez]
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2020/07/01 00:00 [pmc-release]
AID - 10.1109/EMBC.2019.8857759 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:3999-4003. doi: 
      10.1109/EMBC.2019.8857759.