PMID- 31947158
OWN - NLM
STAT- MEDLINE
DCOM- 20200618
LR  - 20200928
IS  - 2694-0604 (Electronic)
IS  - 2375-7477 (Linking)
VI  - 2019
DP  - 2019 Jul
TI  - Towards validating stent induced micro flow patterns in left main coronary artery 
      bifurcations.
PG  - 5749-5752
LID - 10.1109/EMBC.2019.8856419 [doi]
AB  - We investigated if blood flow changes induced through the presence of a stent 
      could be detected using in vitro dynamically scaled 4D Phase-Contrast Magnetic 
      Resonance Imaging (PC-MRI). Using idealized and patient-specific left main 
      coronary artery bifurcations, we 3D-printed the dynamically large scaled 
      geometries and incorporated them into a flow circuit for non-invasive acquisition 
      with a higher effective spatial resolution. We tested the effects of using 
      non-Newtonian and Newtonian fluids for the experiment. We also numerically 
      simulated the same geometries in true scale for comparison using computational 
      fluid dynamics (CFD). We found that the experimental setup increased the 
      effective spatial resolution enough to reveal stent induced blood flow changes 
      close to the vessel wall. Non-Newtonian fluid replicated all of the flow field 
      well with a strong agreement with the computed flow field (R(2) > 0.9). Fine flow 
      structures were not as prominent for the Newtonian compared to non-Newtonian 
      fluid consideration. In the patient-specific geometry, arterial non-planarity 
      increased the difficulty to capture the near wall slow velocity changes. Findings 
      demonstrate the potential to dynamically scale in vitro 4D MRI flow acquisition 
      for micro blood flow considerations.
FAU - Masoud-Ansari, Sina
AU  - Masoud-Ansari S
FAU - Ormiston, John
AU  - Ormiston J
FAU - Webster, Mark
AU  - Webster M
FAU - Pontre, Beau
AU  - Pontre B
FAU - Cowan, Brett
AU  - Cowan B
FAU - Beier, Susann
AU  - Beier S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Annu Int Conf IEEE Eng Med Biol Soc
JT  - Annual International Conference of the IEEE Engineering in Medicine and Biology 
      Society. IEEE Engineering in Medicine and Biology Society. Annual International 
      Conference
JID - 101763872
SB  - IM
MH  - Blood Flow Velocity
MH  - Computer Simulation
MH  - *Coronary Vessels
MH  - Humans
MH  - Hydrodynamics
MH  - *Models, Cardiovascular
MH  - Stents
EDAT- 2020/01/18 06:00
MHDA- 2020/06/19 06:00
CRDT- 2020/01/18 06:00
PHST- 2020/01/18 06:00 [entrez]
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2020/06/19 06:00 [medline]
AID - 10.1109/EMBC.2019.8856419 [doi]
PST - ppublish
SO  - Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:5749-5752. doi: 
      10.1109/EMBC.2019.8856419.