PMID- 31947422 OWN - NLM STAT- MEDLINE DCOM- 20200619 LR - 20200928 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2019 DP - 2019 Jul TI - Excitation Comparison between Multi-site Stimulation using Network-based tDCS and Focal Stimulation using High-definition tDCS. PG - 6884-6887 LID - 10.1109/EMBC.2019.8857287 [doi] AB - Transcranial direct current stimulation (tDCS) has been developed rapidly in recent years and derived various forms which serve as therapeutic tools for neurological disorders. However, differences of stimulation effect among these stimulation strategies have not been fully explored. In this pilot study, we compared the stimulation effect between High-definition tDCS (HD-tDCS) and Network-based tDCS (NB-tDCS) on a healthy subject. HD-tDCS mainly stimulated primary motor cortex with 2mA current and NB-tDCS was designed to stimulate main motor-related areas including primary motor cortex, premotor cortex and supplementary motor area with the same amount of current in total. Cortico-muscular coherence (CMC) derived from EEG/EMG, which measures the synchrony between cortical neural activity and muscles, was collected from isometric wrist extension tasks. The results demonstrated more motor-related regions excited and longer high-level lasting effect after NB-tDCS compared with HD-tDCS, which indicated the potential power of multi-site stimulation. This study might provide some guidance and hints for transcranial stimulation strategies in the future. FAU - Chen, Cheng AU - Chen C FAU - Fang, Yuqi AU - Fang Y FAU - Wang, Xin AU - Wang X FAU - Bao, Shi-Chun AU - Bao SC FAU - Tang, Zhiqiang AU - Tang Z FAU - Tong, Raymond Kai-Yu AU - Tong RK LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Healthy Volunteers MH - Humans MH - Motor Cortex MH - Pilot Projects MH - *Transcranial Direct Current Stimulation MH - Wrist EDAT- 2020/01/18 06:00 MHDA- 2020/06/20 06:00 CRDT- 2020/01/18 06:00 PHST- 2020/01/18 06:00 [entrez] PHST- 2020/01/18 06:00 [pubmed] PHST- 2020/06/20 06:00 [medline] AID - 10.1109/EMBC.2019.8857287 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:6884-6887. doi: 10.1109/EMBC.2019.8857287.