PMID- 31947563
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20240328
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Jan 14
TI  - A Mixture of Phenolic Metabolites of Quercetin Can Decrease Elevated Blood 
      Pressure of Spontaneously Hypertensive Rats Even in Low Doses.
LID - 10.3390/nu12010213 [doi]
LID - 213
AB  - Quercetin is proven to decrease arterial blood pressure when given orally. Its 
      bioavailability is, however, low and, therefore, its metabolites could rather be 
      responsible for this effect. In particular, the colonic metabolites of quercetin, 
      3,4-dihydroxyphenylacetic acid (DHPA), 4-methylcatechol (4MC), and 
      3-(3-hydroxyphenyl)propionic acid (3HPPA), have been previously shown to decrease 
      the blood pressure in spontaneously hypertensive rats (SHR). Interestingly, the 
      mechanisms of action of these three metabolites are different. The aim of this 
      study is hence to investigate if these metabolites can potentiate each other and 
      thus decrease blood pressure in reduced doses. Three double-combinations of 
      previously mentioned metabolites were administered to SHR as infusions to mimic a 
      real biological situation. All combinations significantly decreased the blood 
      pressure in SHR but there were important differences. The effect of DHPA and 4MC 
      was mild and very short. A combination of DHPA with 3HPPA caused more pronounced 
      effects, which were also rather short-lived. The last combination of 3HPPA and 
      4MC caused a long-lasting effect. In conclusion, certain combinations of 
      quercetin metabolites have a more pronounced antihypertensive effect than single 
      metabolites.
FAU - Najmanova, Iveta
AU  - Najmanova I
AD  - Department of Biological and Medical Sciences, Faculty of Pharmacy in Hradec 
      Kralove, Charles University, Akademika Heyrovskeho 1203/8, 500 05 Hradec Kralove, 
      Czech Republic.
FAU - Pourova, Jana
AU  - Pourova J
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, 
      Charles University, Akademika Heyrovskeho 1203/8, 500 05 Hradec Kralove, Czech 
      Republic.
FAU - Mladenka, Premysl
AU  - Mladenka P
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, 
      Charles University, Akademika Heyrovskeho 1203/8, 500 05 Hradec Kralove, Czech 
      Republic.
LA  - eng
GR  - 17-05409S/Grantova Agentura Ceske Republiky/
GR  - CZ.02.1.01/0.0/0.0/16_019/0000841/The ministry of education, youth and sport 
      (CZ)/
PT  - Journal Article
DEP - 20200114
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Catechols)
RN  - 0 (Coumaric Acids)
RN  - 0 (Phenols)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 12GLI7JGB3 (4-methylcatechol)
RN  - 621-54-5 (dihydro-3-coumaric acid)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/pharmacokinetics
MH  - Animals
MH  - Antihypertensive Agents/*pharmacokinetics
MH  - Biological Availability
MH  - Blood Pressure/*drug effects
MH  - Catechols/pharmacokinetics
MH  - Coumaric Acids/pharmacokinetics
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Hypertension/*drug therapy
MH  - Male
MH  - Phenols/*pharmacokinetics
MH  - Quercetin/*chemistry
MH  - Rats
MH  - Rats, Inbred SHR
PMC - PMC7019299
OTO - NOTNLM
OT  - blood pressure
OT  - in vivo
OT  - infusion
OT  - phenolic
OT  - quercetin
OT  - rat
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/18 06:00
MHDA- 2020/11/12 06:00
PMCR- 2020/01/01
CRDT- 2020/01/18 06:00
PHST- 2019/12/18 00:00 [received]
PHST- 2020/01/09 00:00 [revised]
PHST- 2020/01/09 00:00 [accepted]
PHST- 2020/01/18 06:00 [entrez]
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - nu12010213 [pii]
AID - nutrients-12-00213 [pii]
AID - 10.3390/nu12010213 [doi]
PST - epublish
SO  - Nutrients. 2020 Jan 14;12(1):213. doi: 10.3390/nu12010213.