PMID- 31948296 OWN - NLM STAT- MEDLINE DCOM- 20210818 LR - 20220425 IS - 1521-0553 (Electronic) IS - 0894-1939 (Linking) VI - 34 IP - 8 DP - 2021 Aug TI - Effect of Pretreatment of S-Ketamine On Postoperative Depression for Breast Cancer Patients. PG - 883-888 LID - 10.1080/08941939.2019.1710626 [doi] AB - OBJECTIVE: This study aims to investigate the effect of the pretreatment of S-ketamine on postoperative depression (POD) for breast cancer patients with mild/moderate depression. METHODS: The present randomized, double-blinded controlled trial included 303 breast cancer patients with mild/moderate depression from June 2017 to June 2018. All patients were randomly divided into three groups: (1) control group, patients treated with normal saline; (2) racemic ketamine group, patients treated with racemic ketamine; (3) S-ketamine group, patients treated with S-ketamine. Operation time, blood loss and hospital stay and complications were recorded. The Visual Analog Scale (VAS) score was recorded, and the Hamilton Rating Scale for Depression (HAMD-17) scores, serum brain-derived neurotrophic factor (BDNF) and 5-hydroxytryptamine (5-HT) were measured at three days, one week, one month and three months after surgery. RESULTS: No significant difference was found in operation time, bleeding volume and complication rate. In both groups, the VAS scores at one day and three days after surgery were significantly lower. The HAMD-17 scores were significantly lower, and the serum levels of both BDNF and 5-HT were remarkably higher at three days, one week and one month after surgery. Meanwhile, the HAMD-17 scores were remarkably lower, while the serum levels of BDNF and 5-HT were remarkably higher in the S-ketamine group. The BDNF and 5-HT levels were negatively correlated with the HAMD-17 score. CONCLUSION: S-ketamine is more effective for reducing POD for breast cancer patients. FAU - Liu, Peirong AU - Liu P AD - Anesthesiology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China. FAU - Li, Pengyi AU - Li P AD - Anesthesiology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China. FAU - Li, Qingyang AU - Li Q AD - Anesthesiology, Fengcheng Hospital of Fengxian District, Shanghai, China. FAU - Yan, Hongzhu AU - Yan H AD - Anesthesiology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China. FAU - Shi, Xiaowei AU - Shi X AD - Anesthesiology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China. FAU - Liu, Chunliang AU - Liu C AD - Anesthesiology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China. FAU - Zhang, Yu AU - Zhang Y AD - Anesthesiology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China. FAU - Peng, Sheng AU - Peng S AD - Anesthesiology, Seventh People's Hospital of Shanghai University of TCM, Shanghai, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20200116 PL - United States TA - J Invest Surg JT - Journal of investigative surgery : the official journal of the Academy of Surgical Research JID - 8809255 RN - 50LFG02TXD (Esketamine) RN - 690G0D6V8H (Ketamine) SB - IM MH - *Breast Neoplasms/surgery MH - Depression MH - Double-Blind Method MH - Female MH - Humans MH - *Ketamine/therapeutic use MH - Pain, Postoperative/drug therapy/etiology/prevention & control OTO - NOTNLM OT - S-ketamine OT - postoperative depression OT - racemic ketamine EDAT- 2020/01/18 06:00 MHDA- 2021/08/19 06:00 CRDT- 2020/01/18 06:00 PHST- 2020/01/18 06:00 [pubmed] PHST- 2021/08/19 06:00 [medline] PHST- 2020/01/18 06:00 [entrez] AID - 10.1080/08941939.2019.1710626 [doi] PST - ppublish SO - J Invest Surg. 2021 Aug;34(8):883-888. doi: 10.1080/08941939.2019.1710626. Epub 2020 Jan 16.