PMID- 31948334
OWN - NLM
STAT- MEDLINE
DCOM- 20210125
LR  - 20210125
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 30
IP  - 4
DP  - 2020 May
TI  - The action of low doses of persistent organic pollutants (POPs) on mitochondrial 
      function in zebrafish eyes and comparison with hyperglycemia to identify a link 
      between POPs and diabetes.
PG  - 275-283
LID - 10.1080/15376516.2020.1717704 [doi]
AB  - Type 2 diabetes (T2D) is characterized by defects in insulin action to target 
      tissues, resulting in hyperglycemia, insulin resistance, and mitochondrial 
      dysfunction. The eye is one of the organs susceptible to T2D, but knowledge 
      regarding mitochondrial dysfunction in the eyes after hyperglycemia and T2D is 
      based mainly on epidemiological evidence, with little experimental data. 
      Persistent organic pollutants (POPs) are known as endocrine-disrupting chemicals 
      and are associated with uncontrolled glucose and lipid metabolism, leading to the 
      onset of diabetes. To determine the relationship between POPs and T2D, two model 
      systems were developed: glucose-immersed zebrafish to induce hyperglycemia, and 
      zebrafish exposed to low-dose POPs in a water circulating system for three 
      months. To examine the role of mitochondrial function, the activity of 
      mitochondrial complexes I, II, III, and IV from the eyes of the two zebrafish 
      models was measured spectrophotometrically. Enhanced enzymatic activities of 
      mitochondrial complexes III and IV were observed in the eyes of both 
      hyperglycemia and low-dose POPs exposed models, especially in male zebrafish. 
      These results demonstrate that POPs alleviate mitochondrial oxidative 
      phosphorylation (OXPHOS) in a sex-dependent manner through a compensatory 
      mechanism, which is also observed in acute hyperglycemia.
FAU - Ko, Eun
AU  - Ko E
AD  - Interdisciplinary Program of Bioenergy and Biomaterials Graduate School, College 
      of Engineering, Chonnam National University, Gwangju, Republic of Korea.
FAU - Kim, Dayoung
AU  - Kim D
AD  - Interdisciplinary Program of Bioenergy and Biomaterials Graduate School, College 
      of Engineering, Chonnam National University, Gwangju, Republic of Korea.
FAU - Kim, Kitae
AU  - Kim K
AD  - Department of Environmental Engineering, College of Energy and Biotechnology, 
      Seoul National University of Science and Technology, Seoul, Republic of Korea.
FAU - Choi, Moonsung
AU  - Choi M
AD  - Department of Optometry, College of Energy and Biotechnology, Seoul National 
      University of Science and Technology, Seoul, Republic of Korea.
FAU - Shin, Sooim
AU  - Shin S
AD  - Interdisciplinary Program of Bioenergy and Biomaterials Graduate School, College 
      of Engineering, Chonnam National University, Gwangju, Republic of Korea.
AD  - Department of Biotechnology and Bioengineering, College of Engineering, Chonnam 
      National University, Gwangju, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20200128
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Blood Glucose)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 7.1.1.8 (Electron Transport Complex III)
SB  - IM
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Electron Transport Complex III/metabolism
MH  - Electron Transport Complex IV/metabolism
MH  - Hydrocarbons, Chlorinated/*toxicity
MH  - Hyperglycemia/*metabolism
MH  - Mitochondria/*drug effects/metabolism
MH  - Oxidative Phosphorylation
MH  - Persistent Organic Pollutants/*toxicity
MH  - Retina/*drug effects/metabolism
MH  - Zebrafish/*metabolism
OTO - NOTNLM
OT  - Eye
OT  - Zebrafish
OT  - hyperglycemia
OT  - mitochondrial oxidative phosphorylation
OT  - persistent organic pollutant
EDAT- 2020/01/18 06:00
MHDA- 2021/01/26 06:00
CRDT- 2020/01/18 06:00
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2021/01/26 06:00 [medline]
PHST- 2020/01/18 06:00 [entrez]
AID - 10.1080/15376516.2020.1717704 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2020 May;30(4):275-283. doi: 10.1080/15376516.2020.1717704. 
      Epub 2020 Jan 28.