PMID- 31949539
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 1857-9655 (Print)
IS  - 1857-9655 (Electronic)
IS  - 1857-9655 (Linking)
VI  - 7
IP  - 19
DP  - 2019 Oct 15
TI  - Myeloid and Plasmacytoid Dendritic Cells and Cancer - New Insights.
PG  - 3324-3340
LID - 10.3889/oamjms.2019.735 [doi]
AB  - Dendritic cells (DCs) use effective mechanisms to combat antigens and to bring 
      about adaptive immune responses through their ability to stimulate naive T cells. 
      At present, four major cell types are categorised as DCs: Classical or 
      conventional (cDCs), Plasmacytoid (pDCs), Langerhans cells (LCs), and 
      monocyte-derived DCs (Mo-DCs). It was suggested that pDCs, CD1c+ DCs and CD141+ 
      DCs in humans are equivalent to mouse pDCs, CD11b+ DCs and CD8alpha+ DCs, 
      respectively. Human CD141+ DCs compared to mouse CD8alpha+ DCs have remarkable 
      functional and transcriptomic similarities. Characteristic markers, transcription 
      factors, toll-like receptors, T helpers (Th) polarisation, cytokines, etc. of DCs 
      are discussed in this review. Major histocompatibility complex (MHC) I and II 
      antigen presentation, cross-presentation and Th polarisation are defined, and the 
      dual role of DCs in the tumour is discussed. Human DCs are the main immune cells 
      that orchestrate the immune response in the tumour microenvironment.
CI  - Copyright: (c) 2019 Maya Gulubova.
FAU - Gulubova, Maya
AU  - Gulubova M
AD  - Department of General and Clinical Pathology, Medical Faculty, Trakia University, 
      Stara Zagora, Bulgaria.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191013
PL  - North Macedonia
TA  - Open Access Maced J Med Sci
JT  - Open access Macedonian journal of medical sciences
JID - 101662294
PMC - PMC6953922
OTO - NOTNLM
OT  - Classical dendritic cells
OT  - Cross presentation
OT  - MHC I and II antigen presentation
OT  - Plasmacytoid dendritic cells
OT  - Review
OT  - Th polarisation
EDAT- 2020/01/18 06:00
MHDA- 2020/01/18 06:01
PMCR- 2019/10/13
CRDT- 2020/01/18 06:00
PHST- 2019/07/25 00:00 [received]
PHST- 2019/08/21 00:00 [revised]
PHST- 2019/08/22 00:00 [accepted]
PHST- 2020/01/18 06:00 [entrez]
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2020/01/18 06:01 [medline]
PHST- 2019/10/13 00:00 [pmc-release]
AID - OAMJMS-7-3324 [pii]
AID - 10.3889/oamjms.2019.735 [doi]
PST - epublish
SO  - Open Access Maced J Med Sci. 2019 Oct 13;7(19):3324-3340. doi: 
      10.3889/oamjms.2019.735. eCollection 2019 Oct 15.