PMID- 31949591 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200121 IS - 1936-2625 (Electronic) IS - 1936-2625 (Linking) VI - 11 IP - 10 DP - 2018 TI - Alveolar soft-part sarcoma of the prostate: a case report and review of the literature. PG - 5126-5132 AB - Alveolar soft-part sarcoma (ASPS) is a rare malignant soft tissue tumor of uncertain cellular origin. We reported the case of a 21-year-old man with ASPS presenting itself as a markedly vascular tumor of the prostate. Immunohistochemistry showed positive nuclear staining for TFE3, positive cytoplasm staining for MyoD1 and neuron-specific enolase, and negative for S100, CK, synaptophysin, chromogranin A, myogenin and PSA. A dual-color, break-apart fluorescence in situ hybridization (FISH) assay identified the presence of a TFE3 gene fusion in the tumor cells. RT-PCR was performed to confirm the ASPSCR1 (ASPL)/TFE3 fusion transcript product in the tumor tissue. The patient suffered bone metastases 8 months after surgery and died of cachexia 14 months later. ASPS of the prostate should be discussed in terms of differential diagnosis from clinicopathological characteristics, immunophenotypes, and molecular genetic features. CI - IJCEP Copyright (c) 2018. FAU - Wang, Jian-Rong AU - Wang JR AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. FAU - Rao, Qiu AU - Rao Q AD - Department of Pathology, Nanjing Jinling Hospital, School of Medicine, Nanjing University Nanjing 210002, Jiangsu Province, China. FAU - Li, Hui AU - Li H AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. FAU - Wang, Yao-Hui AU - Wang YH AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. FAU - Sun, Yi AU - Sun Y AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. FAU - Si, Hai-Peng AU - Si HP AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. FAU - Shen, Long-Shu AU - Shen LS AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. FAU - Liu, Chun-Yang AU - Liu CY AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. FAU - Zhang, Yi-Fen AU - Zhang YF AD - Department of Pathology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Nanjing 210029, Jiangsu Province, China. LA - eng PT - Case Reports DEP - 20181001 PL - United States TA - Int J Clin Exp Pathol JT - International journal of clinical and experimental pathology JID - 101480565 PMC - PMC6962941 OTO - NOTNLM OT - Alveolar soft-part sarcoma OT - FISH OT - prostate COIS- None. EDAT- 2018/10/01 00:00 MHDA- 2018/10/01 00:01 PMCR- 2018/10/01 CRDT- 2020/01/18 06:00 PHST- 2018/05/30 00:00 [received] PHST- 2018/09/07 00:00 [accepted] PHST- 2020/01/18 06:00 [entrez] PHST- 2018/10/01 00:00 [pubmed] PHST- 2018/10/01 00:01 [medline] PHST- 2018/10/01 00:00 [pmc-release] PST - epublish SO - Int J Clin Exp Pathol. 2018 Oct 1;11(10):5126-5132. eCollection 2018.