PMID- 31949766
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240327
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 11
IP  - 7
DP  - 2018
TI  - Circ-PAX2 promotes proliferation and metastasis by absorbing miR-186 in lung 
      cancer cells.
PG  - 3793-3801
AB  - Circ-RNAs are a type of non-coding-protein RNAs which act as an effector role in 
      many physiological processes. However, the novel function of circ-PAX2 in lung 
      carcinomas is still unidentified. The current study is to detect the expression 
      of circ-PAX2 in lung squamous cell carcinoma (LSCC) tissues and the physiological 
      functions of circ-PAX2. Circ-PAX2 was distinguished in LSCC samples and matched 
      non-tumor samples by human circRNA microarray analysis and was validated to be 
      up-regulated in 86 specimens of LSCC tissues and lung cancer cell lines by 
      qRT-PCR. Functional validation experiments showed that knockdown of circ-PAX2 
      promoted apoptosis of lung carcinoma cells, and then suppressed proliferation and 
      migration of tumor cells. Small interfering RNA (siRNA) to circ-PAX2 inhibited 
      growth in lung tumor cells. Bioinformatics prediction and rescue experiments 
      showed that circ-PAX2 was a target of microRNA-186, confirmed by qRT-PCR and 
      double luciferase reporter assay. On the whole, our findings reveal that 
      circ-PAX2 was up-regulated and may be an oncogene in lung cancer; its function 
      was reducing apoptosis, promoting cell proliferation and migration in lung 
      carcinoma cells, which might be a novel therapeutic targetgene in lung cancer.
CI  - IJCEP Copyright (c) 2018.
FAU - Wang, Lei
AU  - Wang L
AD  - Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou 
      University Yangzhou, China.
FAU - Xu, Cong
AU  - Xu C
AD  - Department of Pathology, The Medical College of Yangzhou University, Yangzhou 
      University Yangzhou, China.
FAU - Wang, Chenghai
AU  - Wang C
AD  - Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou 
      University Yangzhou, China.
AD  - Department of Pathology, The Medical College of Yangzhou University, Yangzhou 
      University Yangzhou, China.
FAU - Gong, Weijuan
AU  - Gong W
AD  - Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for 
      Prevention and Treatment of Senile Disease, Medical College, Yangzhou University 
      Yangzhou, China.
FAU - Zhang, Kefan
AU  - Zhang K
AD  - Department of Pathology, The Medical College of Yangzhou University, Yangzhou 
      University Yangzhou, China.
FAU - Chen, Qiuyue
AU  - Chen Q
AD  - Department of Pathology, The Medical College of Yangzhou University, Yangzhou 
      University Yangzhou, China.
FAU - Zhou, Shishi
AU  - Zhou S
AD  - Department of Pathology, The Medical College of Yangzhou University, Yangzhou 
      University Yangzhou, China.
FAU - Qi, Tingyue
AU  - Qi T
AD  - Department of Radiology, The Affiliated Hospital of Yangzhou University, Yangzhou 
      University Yangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20180701
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6962841
OTO - NOTNLM
OT  - Lung carcinoma
OT  - circ-PAX2
OT  - metastasis
OT  - miR-186
OT  - proliferation
COIS- None.
EDAT- 2018/07/01 00:00
MHDA- 2018/07/01 00:01
PMCR- 2018/07/01
CRDT- 2020/01/18 06:00
PHST- 2018/04/25 00:00 [received]
PHST- 2018/05/27 00:00 [accepted]
PHST- 2020/01/18 06:00 [entrez]
PHST- 2018/07/01 00:00 [pubmed]
PHST- 2018/07/01 00:01 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2018 Jul 1;11(7):3793-3801. eCollection 2018.