PMID- 31949932
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2078-6891 (Print)
IS  - 2219-679X (Electronic)
IS  - 2078-6891 (Linking)
VI  - 10
IP  - 6
DP  - 2019 Dec
TI  - Malignant gastrointestinal neuroectodermal tumor, presenting as a second 
      malignancy after gastric adenocarcinoma: a case report and literature review.
PG  - 1144-1150
LID - 10.21037/jgo.2019.08.04 [doi]
AB  - Malignant gastrointestinal neuroectodermal tumor (GNET), is a rare soft tissue 
      sarcoma. Here we report a case of GNET arising in the intestine of a 33-year-old 
      female, who had been treated for gastric adenocarcinoma with surgery and 
      chemotherapy at the age of 19, in 2001. Since then, she underwent follow-up care 
      annually and kept disease free. Nevertheless, in 2015 she presented with vomiting 
      and was found to have a mass in the small intestine. Surgical excision was 
      performed. Histologically, the tumor was characterized by polygonal cells with 
      clear or eosinophilic cytoplasm, and variably scattered osteoclast-like 
      multinucleated giant cells. Immunohistochemically, the tumor cells showed diffuse 
      and strong expression for S100, but AE1/AE3 cytokeratin, HMB-45 and Melan-A were 
      negative. Genetically, EWSR1 gene rearrangement was detected by fluorescence in 
      situ hybridization (FISH). All these alterations were different from primary 
      gastric adenocarcinoma. Moreover, the tumor gave metastases to ileal mesentery 
      and lung in 1 and 4 years later, respectively. In summary, this is the first 
      report of primary intestinal GNET with multiple metastases in a young woman who 
      had a known history of chemotherapy for gastric adenocarcinoma. In consistence 
      with previous literature, which reported a secondary GNET following chemotherapy 
      for hepatoblastoma, we speculate that the chemotherapy might trigger the 
      rearrangement of EWSR1 and then promote the tumorigenesis of GNET.
CI  - 2019 Journal of Gastrointestinal Oncology. All rights reserved.
FAU - Zhan, Meng-Na
AU  - Zhan MN
AD  - Department of Pathology, Zhongshan Hospital Affiliated to Fudan University, 
      Shanghai 200023, China.
FAU - Yu, Juan
AU  - Yu J
AD  - Department of Pathology, Zhongshan Hospital Affiliated to Fudan University, 
      Shanghai 200023, China.
FAU - Luo, Rong-Kui
AU  - Luo RK
AD  - Department of Pathology, Zhongshan Hospital Affiliated to Fudan University, 
      Shanghai 200023, China.
FAU - Hou, Ying-Yong
AU  - Hou YY
AD  - Department of Pathology, Zhongshan Hospital Affiliated to Fudan University, 
      Shanghai 200023, China.
AD  - Department of Pathology, School of Basic Medical Sciences, Fudan University, 
      Shanghai 200032, China.
LA  - eng
PT  - Case Reports
PL  - China
TA  - J Gastrointest Oncol
JT  - Journal of gastrointestinal oncology
JID - 101557751
PMC - PMC6955011
OTO - NOTNLM
OT  - Gastrointestinal neuroectodermal tumor (GNET)
OT  - gastric neoplasms
OT  - secondary primary
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2020/01/18 06:00
MHDA- 2020/01/18 06:01
PMCR- 2019/12/01
CRDT- 2020/01/18 06:00
PHST- 2020/01/18 06:00 [entrez]
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2020/01/18 06:01 [medline]
PHST- 2019/12/01 00:00 [pmc-release]
AID - jgo-10-06-1144 [pii]
AID - 10.21037/jgo.2019.08.04 [doi]
PST - ppublish
SO  - J Gastrointest Oncol. 2019 Dec;10(6):1144-1150. doi: 10.21037/jgo.2019.08.04.