PMID- 31950002
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2190-1678 (Print)
IS  - 2190-1686 (Electronic)
IS  - 2190-1678 (Linking)
VI  - 11
IP  - 1
DP  - 2020 Jan
TI  - Prospective study on clinical characteristics of Japanese diabetic patients with 
      chronic limb-threatening ischemia presenting Fontaine stage IV.
PG  - 33-40
LID - 10.1007/s13340-019-00399-5 [doi]
AB  - The aim of this prospective cross-sectional study was to reveal clinical 
      characteristics of Japanese diabetic patients with chronic limb-threatening 
      ischemia (CLTI) presenting ischemic unhealed ulcer/gangrene (Fontaine stage IV) 
      in the real-world settings. The present study included 132 Japanese diabetic 
      patients who underwent endovascular therapy for CLTI presenting Fontaine stage 
      IV. The prevalence of diabetes-related complications, as well as prior history of 
      ankle-brachial index (ABI) measurement before CLTI onset, was evaluated adopting 
      multiple imputation (50 times). Duration of diabetes was referred to as time from 
      diagnosis. The patients were aged 70 +/- 10 years, with duration of diabetes 
      23 +/- 12 years. The diabetes-related complications were so common that only 17% 
      (95% confidence interval: 11-24%) and 25% (17-33%) of the population were free 
      from advanced micro- and macroangiopathies, respectively. The clustering of 
      advanced macroangiopathies was not significantly associated with duration of 
      diabetes (P = 0.62). On the other hand, that of advanced microangiopathies was 
      significantly positively associated with duration of diabetes (P = 0.004). 
      However, even in patients with duration of diabetes < 10 years, as many as 63% 
      (38-87%) of patients had at least one advanced microangiopathy. Only 31% (22-39%) 
      of the patients had prior history of ABI measurement before CLTI onset. The 
      history was inversely associated with age (P = 0.005). In conclusion, the 
      advanced diabetes-related complications were highly prevalent, even in those 
      whose diabetes was diagnosed less than a decade before. In addition, only a few 
      patients had ever undergone ABI measurement before CLTI onset.
CI  - (c) The Japan Diabetes Society 2019.
FAU - Takahara, Mitsuyoshi
AU  - Takahara M
AUID- ORCID: 0000-0001-5105-041X
AD  - 1Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka 
      University, 2-2, Yamadaoka, Suita City, Osaka 565-0871 Japan. GRID: 
      grid.136593.b. ISNI: 0000 0004 0373 3971
FAU - Okuno, Shota
AU  - Okuno S
AD  - 2Cardiovascular Center, Kansai Rosai Hospital, 3-1-69, Inabaso, Amagasaki City, 
      Hyogo 660-8511 Japan. GRID: grid.414976.9. ISNI: 0000 0004 0546 3696
FAU - Nakamura, Izumi
AU  - Nakamura I
AD  - 2Cardiovascular Center, Kansai Rosai Hospital, 3-1-69, Inabaso, Amagasaki City, 
      Hyogo 660-8511 Japan. GRID: grid.414976.9. ISNI: 0000 0004 0546 3696
FAU - Iida, Osamu
AU  - Iida O
AD  - 2Cardiovascular Center, Kansai Rosai Hospital, 3-1-69, Inabaso, Amagasaki City, 
      Hyogo 660-8511 Japan. GRID: grid.414976.9. ISNI: 0000 0004 0546 3696
FAU - Tsujimura, Takuya
AU  - Tsujimura T
AD  - 2Cardiovascular Center, Kansai Rosai Hospital, 3-1-69, Inabaso, Amagasaki City, 
      Hyogo 660-8511 Japan. GRID: grid.414976.9. ISNI: 0000 0004 0546 3696
FAU - Hata, Yosuke
AU  - Hata Y
AD  - 2Cardiovascular Center, Kansai Rosai Hospital, 3-1-69, Inabaso, Amagasaki City, 
      Hyogo 660-8511 Japan. GRID: grid.414976.9. ISNI: 0000 0004 0546 3696
FAU - Fujita, Yukihiro
AU  - Fujita Y
AD  - 3Division of Metabolism and Biosystemic Science, Department of Internal Medicine, 
      Asahikawa Medical University, Asahikawa, Hokkaido 078-8510 Japan. GRID: 
      grid.252427.4. ISNI: 0000 0000 8638 2724
FAU - Haneda, Masakazu
AU  - Haneda M
AD  - 3Division of Metabolism and Biosystemic Science, Department of Internal Medicine, 
      Asahikawa Medical University, Asahikawa, Hokkaido 078-8510 Japan. GRID: 
      grid.252427.4. ISNI: 0000 0000 8638 2724
LA  - eng
PT  - Journal Article
DEP - 20190617
PL  - Japan
TA  - Diabetol Int
JT  - Diabetology international
JID - 101553224
PMC - PMC6942079
OTO - NOTNLM
OT  - Critical limb-threatening ischemia
OT  - Diabetes-related complication
OT  - Fontaine stage IV
OT  - Prior history of ankle-brachial index measurement
COIS- Conflict of interestThe authors declare that they have no conflicts of interests 
      associated with this manuscript.
EDAT- 2020/01/18 06:00
MHDA- 2020/01/18 06:01
PMCR- 2020/06/17
CRDT- 2020/01/18 06:00
PHST- 2019/04/07 00:00 [received]
PHST- 2019/06/10 00:00 [accepted]
PHST- 2020/01/18 06:00 [entrez]
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2020/01/18 06:01 [medline]
PHST- 2020/06/17 00:00 [pmc-release]
AID - 399 [pii]
AID - 10.1007/s13340-019-00399-5 [doi]
PST - epublish
SO  - Diabetol Int. 2019 Jun 17;11(1):33-40. doi: 10.1007/s13340-019-00399-5. 
      eCollection 2020 Jan.