PMID- 31950375
OWN - NLM
STAT- MEDLINE
DCOM- 20210818
LR  - 20210818
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 33
IP  - 3
DP  - 2020 Jun
TI  - Recent insights into sodium and potassium handling by the aldosterone-sensitive 
      distal nephron: a review of the relevant physiology.
PG  - 431-445
LID - 10.1007/s40620-019-00684-1 [doi]
AB  - In recent years, our understanding of the physiology of the aldosterone-sensitive 
      distal nephron (ASDN) has greatly advanced thanks to the discovery of the complex 
      with-no-lysine kinase (WNK) signaling and the molecular characterization of the 
      epithelial sodium channel (ENaC). A series of studies, initially focused on rare 
      tubulopathies such as Gordon and Liddle syndromes, eventually led to a partial 
      elucidation of the so-called "aldosterone paradox", the traditional explanation 
      of the physiology of such disparate conditions such as hyperkalemia and low 
      effective arterial blood volume. The physiology of the ASDN is herein illustrated 
      in light of the novel acquisitions in an easy-to-understand fashion, with the aim 
      of giving the practicing nephrologist a solid "first glance" into this exciting 
      but challenging field. Focus is on ion channels and transporters, their 
      regulation by key hormones such as aldosterone and angiotensin II, and dietary 
      implications.
FAU - Rossi, Giovanni Maria
AU  - Rossi GM
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Parma, Parma, Italy.
AD  - Dipartimento di Medicina e Chirurgia, Universita di Parma, Via Gramsci 14, 43100, 
      Parma, Italy.
FAU - Regolisti, Giuseppe
AU  - Regolisti G
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Parma, Parma, Italy.
AD  - Dipartimento di Medicina e Chirurgia, Universita di Parma, Via Gramsci 14, 43100, 
      Parma, Italy.
FAU - Peyronel, Francesco
AU  - Peyronel F
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Parma, Parma, Italy.
AD  - Dipartimento di Medicina e Chirurgia, Universita di Parma, Via Gramsci 14, 43100, 
      Parma, Italy.
FAU - Fiaccadori, Enrico
AU  - Fiaccadori E
AUID- ORCID: 0000-0002-6532-7675
AD  - UO Nefrologia, Azienda Ospedaliero-Universitaria Parma, Parma, Italy. 
      enrico.fiaccadori@unipr.it.
AD  - Dipartimento di Medicina e Chirurgia, Universita di Parma, Via Gramsci 14, 43100, 
      Parma, Italy. enrico.fiaccadori@unipr.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200116
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Epithelial Sodium Channels)
RN  - 4964P6T9RB (Aldosterone)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - *Aldosterone
MH  - Epithelial Sodium Channels
MH  - Humans
MH  - Nephrons/metabolism
MH  - Potassium
MH  - *Sodium/metabolism
OTO - NOTNLM
OT  - ASDN
OT  - ENaC
OT  - NCC
OT  - ROMK
OT  - WNK
EDAT- 2020/01/18 06:00
MHDA- 2021/08/19 06:00
CRDT- 2020/01/18 06:00
PHST- 2019/08/18 00:00 [received]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2021/08/19 06:00 [medline]
PHST- 2020/01/18 06:00 [entrez]
AID - 10.1007/s40620-019-00684-1 [pii]
AID - 10.1007/s40620-019-00684-1 [doi]
PST - ppublish
SO  - J Nephrol. 2020 Jun;33(3):431-445. doi: 10.1007/s40620-019-00684-1. Epub 2020 Jan 
      16.