PMID- 31951783
OWN - NLM
STAT- MEDLINE
DCOM- 20201207
LR  - 20201214
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 42
IP  - 2
DP  - 2020 Feb
TI  - Lower limb muscle magnetic resonance imaging in Chinese patients with myotonic 
      dystrophy type 1.
PG  - 170-177
LID - 10.1080/01616412.2020.1716494 [doi]
AB  - Objectives: Muscle magnetic resonance imaging (MRI) is a reliable noninvasion 
      tool for detecting muscle abnormalities of myopathies. This study aimed to 
      investigate the MRI features of lower limb muscles in Chinese patients with 
      myotonic dystrophy type 1 (DM1) and to evaluate the correlation between clinical 
      factors and muscle MRI.Methods: We retrospectively reviewed the medical records 
      and lower limb muscle MRI in 24 Chinese DM1 patients. Muscular Impairment Rating 
      Scale (MIRS) was used to assess the clinical muscular impairment. Modified 
      Mercuri's scale was used to assess the degree of fatty infiltration. Spearman 
      rank correlation test was used to analyze the relationship between fatty 
      degeneration score with age, age of onset, disease duration, MIRS grading and 
      creatinine kinase (CK) level.Results: Fatty infiltration was found in 22 of 24 
      DM1 patients and 8 patients were asymmetrically affected. The medial 
      gastrocnemius was the most affected muscle, followed by soleus and tibialis 
      anterior muscles in lower legs. At thigh level, the anterior compartment was 
      usually the most affected region with the rectus femoris relatively spared. 79.2% 
      of DM1 patients had edema in lower limb muscles. The total mean score of fatty 
      infiltration correlated with MIRS grading, age and disease duration but did not 
      correlate with the age of onset or CK level.Conclusion: Here, we found fatty 
      infiltration present in most Chinese DM1 patients with a selective involvement 
      pattern. There is a correlation between the total mean score of fatty 
      infiltration and MIRS grading, age and disease duration.
FAU - Song, Jia
AU  - Song J
AD  - Department of Neurology, People's Hospital of Zhengzhou University, Henan 
      Provincial People's Hospital, Henan, China.
FAU - Fu, Jun
AU  - Fu J
AD  - Department of Neurology, People's Hospital of Zhengzhou University, Henan 
      Provincial People's Hospital, Henan, China.
FAU - Ma, Mingming
AU  - Ma M
AD  - Department of Neurology, People's Hospital of Zhengzhou University, Henan 
      Provincial People's Hospital, Henan, China.
FAU - Pang, Mi
AU  - Pang M
AD  - Department of Neurology, People's Hospital of Zhengzhou University, Henan 
      Provincial People's Hospital, Henan, China.
FAU - Li, Gang
AU  - Li G
AD  - Department of Neurology, People's Hospital of Zhengzhou University, Henan 
      Provincial People's Hospital, Henan, China.
FAU - Gao, Li
AU  - Gao L
AD  - Department of Radiology, Henan Provincial People's Hospital, People's Hospital of 
      Zhengzhou University, Henan, China.
FAU - Zhang, Jiewen
AU  - Zhang J
AD  - Department of Neurology, People's Hospital of Zhengzhou University, Henan 
      Provincial People's Hospital, Henan, China.
LA  - eng
PT  - Journal Article
DEP - 20200117
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Adult
MH  - Creatine Kinase/blood
MH  - Female
MH  - Humans
MH  - Lower Extremity/*diagnostic imaging/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*diagnostic imaging/pathology
MH  - Myotonic Dystrophy/blood/*diagnostic imaging/pathology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Lower limb muscle
OT  - chinese patients
OT  - magnetic resonance imaging
OT  - muscular Impairment Rating Scale
OT  - myotonic dystrophy type 1
EDAT- 2020/01/18 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/01/18 06:00
PHST- 2020/01/18 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/01/18 06:00 [entrez]
AID - 10.1080/01616412.2020.1716494 [doi]
PST - ppublish
SO  - Neurol Res. 2020 Feb;42(2):170-177. doi: 10.1080/01616412.2020.1716494. Epub 2020 
      Jan 17.