PMID- 31952131
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20221207
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Jan 15
TI  - Effects of Daily Low-Dose Date Consumption on Glycemic Control, Lipid Profile, 
      and Quality of Life in Adults with Pre- and Type 2 Diabetes: A Randomized 
      Controlled Trial.
LID - 10.3390/nu12010217 [doi]
LID - 217
AB  - Dates have a low glycemic index and are a source of antioxidants but, 
      nevertheless, contain more than 70% sugar. This study aims to assess the effects 
      of date consumption (three dates daily) on glycemic profile (HbA1c), body mass 
      index (BMI), quality of life, and lipid profile, including total cholesterol, 
      triglyceride, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) 
      in terms of safety for type 2 diabetic mellitus (T2DM) subjects. A randomized 
      controlled trial was conducted with a sample of 100 T2DM subjects (39 male and 61 
      female) randomly assigned in two groups. The first group received three dates 
      daily for 16 weeks, and the control group avoided date consumption. After a 
      16-week follow-up period, the study results showed an improvement of lipid 
      profile with a statistically significant decrease in total cholesterol of ∆ = 
      -0.209 mmol/L (confidence interval (CI) 95% -0.358, -0.059; p < 0.05) and in LDL 
      of ∆ = -0.171 mmol/L (CI 95% -0.358, 0.016) in the group receiving three dates 
      daily. Intra-group mean differences of BMI were not statistically different in 
      both groups after 16 weeks of date consumption. Even HbA1c did not change, both 
      within and between groups after date consumption (∆ = 0.087%; CI 95% -0.086, 
      0.261). Between groups, mean difference changes (intervention minus control) 
      showed a statistically significant improvement of quality of life index of ∆ = +/- 
      30.66 points (CI 95% 12.45, 48.23) due to the consequent improvement in mental 
      health. Although the definitive effect of dose/intake response of date 
      consumption on Hb1Ac, lipid profile, and BMI in T2DM subjects is still to be 
      established, the study suggests that dates could potentially have a beneficial 
      effect on lipid profile, especially in reducing total cholesterol and elevating 
      HDL, because of its high polyphenolic content. In addition, a low-moderate 
      consumption of dates did not impact glucose levels because of dates' low glycemic 
      index.
FAU - Alalwan, Tariq A
AU  - Alalwan TA
AUID- ORCID: 0000-0002-7693-4542
AD  - Department of Biology, College of Science, University of Bahrain, P.O. Box 32038, 
      Sakhir, Bahrain.
FAU - Perna, Simone
AU  - Perna S
AUID- ORCID: 0000-0002-2720-1473
AD  - Department of Biology, College of Science, University of Bahrain, P.O. Box 32038, 
      Sakhir, Bahrain.
FAU - Mandeel, Qaher A
AU  - Mandeel QA
AD  - Department of Biology, College of Science, University of Bahrain, P.O. Box 32038, 
      Sakhir, Bahrain.
FAU - Abdulhadi, Aalaa
AU  - Abdulhadi A
AD  - Department of Biology, College of Science, University of Bahrain, P.O. Box 32038, 
      Sakhir, Bahrain.
FAU - Alsayyad, Adel Salman
AU  - Alsayyad AS
AD  - Public Health Directorate, Ministry of Health, Manama, Bahrain.
AD  - Department of Family and Community Medicine, College of Medicine and Medical 
      Sciences, Arabian Gulf University, Manama, Bahrain.
FAU - D'Antona, Giuseppe
AU  - D'Antona G
AD  - CRIAMS-Sport Medicine Centre, University of Pavia, 27058 Voghera, Italy.
FAU - Negro, Massimo
AU  - Negro M
AUID- ORCID: 0000-0002-9159-9287
AD  - CRIAMS-Sport Medicine Centre, University of Pavia, 27058 Voghera, Italy.
FAU - Riva, Antonella
AU  - Riva A
AD  - Research and Development Department, Indena SpA, 20139 Milan, Italy.
FAU - Petrangolini, Giovanna
AU  - Petrangolini G
AD  - Research and Development Department, Indena SpA, 20139 Milan, Italy.
FAU - Allegrini, Pietro
AU  - Allegrini P
AD  - Research and Development Department, Indena SpA, 20139 Milan, Italy.
FAU - Rondanelli, Mariangela
AU  - Rondanelli M
AUID- ORCID: 0000-0001-8336-4851
AD  - IRCCS Mondino Foundation, 27100 Pavia, Italy.
AD  - Department of Public Health, Experimental and Forensic Medicine, Unit of Human 
      and Clinical Nutrition, University of Pavia, 27100 Pavia, Italy.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200115
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipids)
SB  - IM
MH  - *Blood Glucose
MH  - *Diabetes Mellitus, Type 2
MH  - Diet
MH  - Female
MH  - *Fruit
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Lipids/*blood
MH  - Male
MH  - *Phoeniceae
MH  - Physical Abuse
MH  - *Prediabetic State
MH  - Quality of Life
PMC - PMC7019638
OTO - NOTNLM
OT  - antioxidants
OT  - dates
OT  - diabetes
OT  - inflammation
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/19 06:00
MHDA- 2020/11/18 06:00
PMCR- 2020/01/01
CRDT- 2020/01/19 06:00
PHST- 2019/11/10 00:00 [received]
PHST- 2019/11/27 00:00 [revised]
PHST- 2019/12/02 00:00 [accepted]
PHST- 2020/01/19 06:00 [entrez]
PHST- 2020/01/19 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - nu12010217 [pii]
AID - nutrients-12-00217 [pii]
AID - 10.3390/nu12010217 [doi]
PST - epublish
SO  - Nutrients. 2020 Jan 15;12(1):217. doi: 10.3390/nu12010217.