PMID- 31952612
OWN - NLM
STAT- MEDLINE
DCOM- 20200603
LR  - 20200603
IS  - 1879-1344 (Electronic)
IS  - 0144-8617 (Linking)
VI  - 232
DP  - 2020 Mar 15
TI  - Puff pastry-like chitosan/konjac glucomannan matrix with thrombin-occupied 
      microporous starch particles as a composite for hemostasis.
PG  - 115814
LID - S0144-8617(19)31482-1 [pii]
LID - 10.1016/j.carbpol.2019.115814 [doi]
AB  - Hemorrhage control is key for reducing mortality following severe trauma. In this 
      study, we produced a puff pastry-like chitosan/konjac glucomannan matrix loaded 
      with thrombin-occupied microporous starch particles to initiate hemostasis. The 
      composite showed a hierarchical porous structure system consisting of porous and 
      rough structures with evenly distributed microporous starch particles. Thrombin 
      was evenly and independently distributed on the microporous starch particles 
      within the hierarchical system and served to accelerate hemostasis. Meanwhile, 
      the composite displayed excellent water absorption capacity, high zeta potential, 
      roughness, and porosity. The composite was found to elicit desirable pro-thrombin 
      time (PT), activated partial thrombin time (APTT), and whole blood clotting 
      indices (BCI). Experiments using animal models demonstrated that the composite 
      could effectively control wound hemorrhage. Furthermore, the composite showed 
      good biocompatibility and effective degradability. Together, our results show 
      that the puff pastry-like hemostat with hierarchical porous structure offers 
      significant potential for use in hemostasis control.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Shi, Zhenghui
AU  - Shi Z
AD  - State Key Laboratory of Silkworm Genome Biology, College of Textile and Garments, 
      Southwest University, Chongqing 400715, China.
FAU - Lan, Guangqian
AU  - Lan G
AD  - State Key Laboratory of Silkworm Genome Biology, College of Textile and Garments, 
      Southwest University, Chongqing 400715, China; Chongqing Engineering Research 
      Center of Biomaterial Fiber and Modern Textile, Chongqing 400715, China.
FAU - Hu, Enling
AU  - Hu E
AD  - State Key Laboratory of Silkworm Genome Biology, College of Textile and Garments, 
      Southwest University, Chongqing 400715, China.
FAU - Lu, Fei
AU  - Lu F
AD  - State Key Laboratory of Silkworm Genome Biology, College of Textile and Garments, 
      Southwest University, Chongqing 400715, China; Chongqing Engineering Research 
      Center of Biomaterial Fiber and Modern Textile, Chongqing 400715, China.
FAU - Qian, Ping
AU  - Qian P
AD  - Jiangsu Key Laboratory of Sericultural Biology and Biotechnology, School of 
      Biotechnology, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 
      China.
FAU - Liu, Jiawei
AU  - Liu J
AD  - Heaquama Biomaterial Co. Ltd (Soochow), Soochow, China.
FAU - Dai, Fangyin
AU  - Dai F
AD  - State Key Laboratory of Silkworm Genome Biology, College of Textile and Garments, 
      Southwest University, Chongqing 400715, China.
FAU - Xie, Ruiqi
AU  - Xie R
AD  - State Key Laboratory of Silkworm Genome Biology, College of Textile and Garments, 
      Southwest University, Chongqing 400715, China; Chongqing Engineering Research 
      Center of Biomaterial Fiber and Modern Textile, Chongqing 400715, China. 
      Electronic address: xie.ruiqi@connect.polyu.hk.
LA  - eng
PT  - Journal Article
DEP - 20200107
PL  - England
TA  - Carbohydr Polym
JT  - Carbohydrate polymers
JID - 8307156
RN  - 0 (Hemostatics)
RN  - 0 (Mannans)
RN  - 36W3E5TAMG ((1-6)-alpha-glucomannan)
RN  - 9005-25-8 (Starch)
RN  - 9012-76-4 (Chitosan)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Chitosan/*chemistry
MH  - Hemostatics/*chemistry
MH  - Mannans/*chemistry
MH  - Particle Size
MH  - Porosity
MH  - Starch/*chemistry
MH  - Surface Properties
MH  - Thrombin/*chemistry
OTO - NOTNLM
OT  - Chitosan
OT  - Hemorrhage control
OT  - Hierarchical porous structure system
OT  - Konjac glucomannan
OT  - Microporous starch particle
OT  - Thrombin
EDAT- 2020/01/19 06:00
MHDA- 2020/06/04 06:00
CRDT- 2020/01/19 06:00
PHST- 2019/10/24 00:00 [received]
PHST- 2019/12/24 00:00 [revised]
PHST- 2019/12/29 00:00 [accepted]
PHST- 2020/01/19 06:00 [entrez]
PHST- 2020/01/19 06:00 [pubmed]
PHST- 2020/06/04 06:00 [medline]
AID - S0144-8617(19)31482-1 [pii]
AID - 10.1016/j.carbpol.2019.115814 [doi]
PST - ppublish
SO  - Carbohydr Polym. 2020 Mar 15;232:115814. doi: 10.1016/j.carbpol.2019.115814. Epub 
      2020 Jan 7.