PMID- 31953470
OWN - NLM
STAT- MEDLINE
DCOM- 20201111
LR  - 20240328
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jan 17
TI  - The association between oxidative stress and corneal hysteresis in patients with 
      glaucoma.
PG  - 545
LID - 10.1038/s41598-020-57520-x [doi]
LID - 545
AB  - Systemic antioxidative status has been implicated in glaucoma pathogenesis. 
      Additionally, corneal hysteresis (CH) may contribute to glaucoma progression. 
      Here, we evaluated the relationship between biological antioxidant potential 
      (BAP) and CH. This study included 103 patients with open-angle glaucoma (OAG). We 
      used a free radical analyzer to measure BAP, and an ocular response analyzer to 
      measure CH and corneal resistance factor (CRF). We evaluated the relationship 
      between systemic oxidative stress and other clinical parameters with Spearman's 
      rank correlation test and a multi-regression analysis. BAP was not correlated to 
      either CH or CRF in the male or female OAG patients. BAP was correlated to both 
      CH and CRF in the female OAG patients older than 57 years (r = 0.51, P = 0.003; 
      r = 0.49, P = 0.004), but uncorrelated in the female OAG patients younger than 57 
      years. Multiple regression analysis revealed that BAP independently contributed 
      to CH (P = 0.025) and CRF (P = 0.015) in the older female OAG patients. Systemic 
      oxidative stress may significantly affect the viscoelasticity of the cornea in 
      older female OAG patients. Future studies are needed to confirm that low systemic 
      antioxidative status and low corneal hysteresis contribute to glaucoma 
      pathogenesis.
FAU - Uchida, Keiko
AU  - Uchida K
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Himori, Noriko
AU  - Himori N
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Hashimoto, Kazuki
AU  - Hashimoto K
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Shiga, Yukihiro
AU  - Shiga Y
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
AD  - Department of Ophthalmic Imaging and Information Analytics, Tohoku University 
      Graduate School of Medicine, Sendai, Japan.
FAU - Tsuda, Satoru
AU  - Tsuda S
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Omodaka, Kazuko
AU  - Omodaka K
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
FAU - Nakazawa, Toru
AU  - Nakazawa T
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan. ntoru@oph.med.tohoku.ac.jp.
AD  - Collaborative Program for Ophthalmic Drug Discovery, Tohoku University Graduate 
      School of Medicine, Sendai, Japan. ntoru@oph.med.tohoku.ac.jp.
AD  - Department of Ophthalmic Imaging and Information Analytics, Tohoku University 
      Graduate School of Medicine, Sendai, Japan. ntoru@oph.med.tohoku.ac.jp.
AD  - Department of Retinal Disease Control, Tohoku University Graduate School of 
      Medicine, Sendai, Japan. ntoru@oph.med.tohoku.ac.jp.
AD  - Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of 
      Medicine, Sendai, Japan. ntoru@oph.med.tohoku.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200117
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Aged
MH  - Cornea/*pathology
MH  - Female
MH  - Glaucoma/*metabolism/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Oxidative Stress
MH  - Retrospective Studies
PMC - PMC6969044
COIS- The authors declare no competing interests.
EDAT- 2020/01/19 06:00
MHDA- 2020/11/12 06:00
PMCR- 2020/01/17
CRDT- 2020/01/19 06:00
PHST- 2019/08/16 00:00 [received]
PHST- 2019/11/11 00:00 [accepted]
PHST- 2020/01/19 06:00 [entrez]
PHST- 2020/01/19 06:00 [pubmed]
PHST- 2020/11/12 06:00 [medline]
PHST- 2020/01/17 00:00 [pmc-release]
AID - 10.1038/s41598-020-57520-x [pii]
AID - 57520 [pii]
AID - 10.1038/s41598-020-57520-x [doi]
PST - epublish
SO  - Sci Rep. 2020 Jan 17;10(1):545. doi: 10.1038/s41598-020-57520-x.