PMID- 31954314
OWN - NLM
STAT- MEDLINE
DCOM- 20200826
LR  - 20200826
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 129
DP  - 2020 Apr
TI  - Protective effects of lycopene against AFB(1)-induced erythrocyte dysfunction and 
      oxidative stress in mice.
PG  - 103-108
LID - S0034-5288(18)31410-3 [pii]
LID - 10.1016/j.rvsc.2020.01.015 [doi]
AB  - To evaluate the protective role of lycopene (LYC) against aflatoxin B(1) 
      (AFB(1))-induced erythrocyte dysfunction and oxidative stress, male kunming mice 
      were treated with LYC (5 mg/kg) and/or AFB(1) (0.75 mg/kg) by intragastric 
      administration for 30 d. Hematological indices were detected to assess 
      erythrocyte function. The erythrocytes C3b receptor rate (E-C3bRR) and 
      erythrocytes C3b immune complex rosette rate (E-ICRR) were detected to assess 
      erythrocyte immune function. Hydrogen peroxide (H(2)O(2)) and malondialdehyde 
      (MDA) contents and superoxide dismutase (SOD) and catalase (CAT) activities were 
      determined to evaluate erythrocyte oxidative stress. The results showed that LYC 
      administration significantly relieved AFB(1)-induced erythrocyte dysfunction by 
      increasing the levels of red blood cell count (RBC), hemoglobin (HGB) and 
      hematocrit (HCT), as well as reducing red blood cell volume distribution width 
      (RDW) level, while the levels of mean corpuscular volume (MCV), mean corpuscular 
      hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean 
      platelet volume (MPV) had no significant differences among the four groups. 
      Besides, LYC ameliorated AFB1-induced erythrocyte immune dysfunction by 
      increasing E-C3bRR and decreasing E-ICRR. Furthermore, LYC also alleviated 
      AFB(1)-induced erythrocyte oxidative stress by decreasing H(2)O(2) and MDA 
      contents and increasing SOD and CAT activities. These results indicated that LYC 
      protected against AFB(1)-induced erythrocyte dysfunction and oxidative stress in 
      mice. The findings could lead a possible therapeutics for the management of 
      AFB(1)-induced erythrocyte toxicity.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Wang, Peiyan
AU  - Wang P
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Xu, Feibo
AU  - Xu F
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Huang, Wanyue
AU  - Huang W
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Ji, Qiang
AU  - Ji Q
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Han, Yanfei
AU  - Han Y
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Shao, Bing
AU  - Shao B
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Li, Yanfei
AU  - Li Y
AD  - Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, 
      College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, 
      China. Electronic address: liyanfei@neau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20200113
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Antioxidants)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - 9N2N2Y55MH (Aflatoxin B1)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - SB0N2N0WV6 (Lycopene)
SB  - IM
MH  - Aflatoxin B1/*toxicity
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Erythrocyte Indices
MH  - Erythrocytes/*drug effects
MH  - Hematocrit
MH  - Hydrogen Peroxide
MH  - Lycopene/*pharmacology
MH  - Male
MH  - Malondialdehyde
MH  - Mice
MH  - Oxidative Stress/*drug effects
OTO - NOTNLM
OT  - Aflatoxin B(1)
OT  - Erythrocyte dysfunction
OT  - Lycopene
OT  - Oxidative stress
COIS- Declaration of Competing Interest The authors declare no potential conflicts.
EDAT- 2020/01/19 06:00
MHDA- 2020/08/28 06:00
CRDT- 2020/01/19 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2019/11/24 00:00 [revised]
PHST- 2020/01/13 00:00 [accepted]
PHST- 2020/01/19 06:00 [pubmed]
PHST- 2020/08/28 06:00 [medline]
PHST- 2020/01/19 06:00 [entrez]
AID - S0034-5288(18)31410-3 [pii]
AID - 10.1016/j.rvsc.2020.01.015 [doi]
PST - ppublish
SO  - Res Vet Sci. 2020 Apr;129:103-108. doi: 10.1016/j.rvsc.2020.01.015. Epub 2020 Jan 
      13.