PMID- 31954515
OWN - NLM
STAT- MEDLINE
DCOM- 20200923
LR  - 20200923
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 523
IP  - 4
DP  - 2020 Mar 19
TI  - Brain-specific chemokine FAM19A5 induces hypothalamic inflammation.
PG  - 829-834
LID - S0006-291X(20)30077-2 [pii]
LID - 10.1016/j.bbrc.2019.12.119 [doi]
AB  - The cytokine-like protein FAM19A5 is highly expressed in the brain, but little is 
      known about its functions there. Here, we found that FAM19A5 was expressed in 
      mouse hypothalamic cells expressing proopiomelanocortin (POMC) and neuropeptide Y 
      (NPY)/agouti-related peptide (AgRP), and in the microglia. Tumor necrosis 
      factor-alpha (TNF-alpha), which induces inflammatory sickness responses, greatly 
      increased hypothalamic expression of FAM19A5. Knockdown of FAM19A5 expression 
      resulted in decreased TNF-alpha-induced anorexia, body weight loss and TNF-alpha-induced 
      expression of inflammatory factors. In contrast, intracerebroventricular 
      administration of FAM19A5 induced anorexia, body weight loss and hyperthermia, 
      together with increased expression of inflammatory factors. FAM19A5 injection 
      also induced increases in c-fos activation and POMC mRNA level in hypothalamic 
      POMC neurons. Together, these results suggest that FAM19A5 plays an important 
      role in hypothalamic inflammatory responses.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Kang, Dasol
AU  - Kang D
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea.
FAU - Kim, Han Rae
AU  - Kim HR
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea; Department of Pharmacology and Physiology, 
      School of Medicine & Health Sciences, The George Washington University, USA, 
      20037.
FAU - Kim, Kwang Kon
AU  - Kim KK
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea.
FAU - Kim, Dong Hee
AU  - Kim DH
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea.
FAU - Jeong, Bora
AU  - Jeong B
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea.
FAU - Jin, Sungho
AU  - Jin S
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea.
FAU - Park, Jeong Woo
AU  - Park JW
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea.
FAU - Seong, Jae Young
AU  - Seong JY
AD  - Graduate School of Medicine, Korea University, Seoul, 02841, South Korea.
FAU - Lee, Byung Ju
AU  - Lee BJ
AD  - Department of Biological Sciences, College of Natural Sciences, University of 
      Ulsan, Ulsan, 44610, South Korea. Electronic address: bjlee@ulsan.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200115
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Cytokines)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Tafa5 protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
SB  - IM
MH  - Animals
MH  - Cytokines/administration & dosage/*metabolism/pharmacology
MH  - Humans
MH  - Hypothalamus/drug effects/*metabolism/*pathology
MH  - Inflammation/*metabolism
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Neurons/drug effects/metabolism
MH  - Organ Specificity/drug effects
MH  - Pro-Opiomelanocortin/metabolism
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Tumor Necrosis Factor-alpha/administration & dosage
OTO - NOTNLM
OT  - Anorexia
OT  - Hyperthermia
OT  - Hypothalamic inflammation
OT  - Proinflammatory cytokines
OT  - Sickness responses
OT  - Tumor necrosis factor-alpha (TNF-alpha)
EDAT- 2020/01/20 06:00
MHDA- 2020/09/24 06:00
CRDT- 2020/01/20 06:00
PHST- 2019/12/03 00:00 [received]
PHST- 2019/12/25 00:00 [accepted]
PHST- 2020/01/20 06:00 [pubmed]
PHST- 2020/09/24 06:00 [medline]
PHST- 2020/01/20 06:00 [entrez]
AID - S0006-291X(20)30077-2 [pii]
AID - 10.1016/j.bbrc.2019.12.119 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2020 Mar 19;523(4):829-834. doi: 
      10.1016/j.bbrc.2019.12.119. Epub 2020 Jan 15.