PMID- 31955812
OWN - NLM
STAT- MEDLINE
DCOM- 20200428
LR  - 20200428
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Linking)
VI  - 221
DP  - 2020 Mar
TI  - Myocardial fibrosis and the effect of primary prophylactic defibrillator 
      implantation in patients with non-ischemic systolic heart failure-DANISH-MRI.
PG  - 165-176
LID - S0002-8703(19)30351-5 [pii]
LID - 10.1016/j.ahj.2019.10.020 [doi]
AB  - AIMS: Patients with non-ischemic systolic heart failure have an increased risk of 
      sudden cardiac death (SCD). Myocardial fibrosis, detected as late gadolinium 
      enhancement (LGE) with cardiac magnetic resonance (CMR), has been shown to 
      predict all-cause mortality. We hypothesized that LGE can identify patients with 
      non-ischemic heart failure who will benefit from ICD implantation. METHODS AND 
      RESULTS: In this prospective observational sub-study of the Danish Study to 
      Assess the Efficacy of ICDs in Patients with Nonischemic Systolic Heart Failure 
      on Mortality (DANISH), 252 patients underwent CMR. LGE was quantified by the full 
      width/half maximum method. The primary endpoint was all-cause mortality. LGE 
      could be adequately assessed in 236 patients, median age was 61 years and median 
      duration of heart failure was 14 months; there were 108 patients (46%) randomized 
      to ICD. Median follow-up time was 5.3 years. Median left ventricular ejection 
      fraction on CMR was 35%. In all, 50 patients died. LGE was present in 113 
      patients (48%). The presence of LGE was an independent predictor of all-cause 
      mortality (HR 1.82; 95% CI 1.002-3.29; P = .049) after adjusting for known 
      cardiovascular risk factors. ICD implantation did not impact all-cause mortality, 
      for either patients with LGE (HR 1.18; 95% CI 0.59-2.38; P = .63), or for 
      patients without LGE (HR 1.00; 95% CI 0.39-2.53; P = .99), (P for interaction 
      =0.79). CONCLUSION: In patients with non-ischemic systolic heart failure, LGE 
      predicted all-cause mortality. However, in this cohort, LGE did not identify a 
      group of patients who survived longer by receiving an ICD.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Elming, Marie Bayer
AU  - Elming MB
AD  - Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark. Electronic address: marie.bayer.elming@regionh.dk.
FAU - Hammer-Hansen, Sophia
AU  - Hammer-Hansen S
AD  - Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Voges, Inga
AU  - Voges I
AD  - Department of Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, 
      London, UK.
FAU - Nyktari, Eva
AU  - Nyktari E
AD  - Department of Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, 
      London, UK.
FAU - Raja, Anna Axelsson
AU  - Raja AA
AD  - Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Svendsen, Jesper Hastrup
AU  - Svendsen JH
AD  - Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Pehrson, Steen
AU  - Pehrson S
AD  - Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Signorovitch, James
AU  - Signorovitch J
AD  - Analysis Group Inc., Boston, MA, USA.
FAU - Kober, Lars
AU  - Kober L
AD  - Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Prasad, Sanjay K
AU  - Prasad SK
AD  - Department of Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, 
      London, UK.
FAU - Thune, Jens Jakob
AU  - Thune JJ
AD  - Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, 
      Denmark; Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, 
      Copenhagen, Denmark.
LA  - eng
GR  - BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20191224
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
SB  - IM
CIN - Am Heart J. 2020 Mar;221:177-179. PMID: 31937405
MH  - Aged
MH  - Death, Sudden, Cardiac/*prevention & control
MH  - *Defibrillators, Implantable
MH  - Denmark
MH  - Female
MH  - Fibrosis
MH  - Heart/*diagnostic imaging
MH  - Heart Failure, Systolic/*therapy
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - Myocardium/*pathology
MH  - Risk Assessment
EDAT- 2020/01/21 06:00
MHDA- 2020/04/29 06:00
CRDT- 2020/01/21 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2019/10/30 00:00 [accepted]
PHST- 2020/01/21 06:00 [pubmed]
PHST- 2020/04/29 06:00 [medline]
PHST- 2020/01/21 06:00 [entrez]
AID - S0002-8703(19)30351-5 [pii]
AID - 10.1016/j.ahj.2019.10.020 [doi]
PST - ppublish
SO  - Am Heart J. 2020 Mar;221:165-176. doi: 10.1016/j.ahj.2019.10.020. Epub 2019 Dec 
      24.