PMID- 31957486
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20220413
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 39
IP  - 4
DP  - 2020 Apr
TI  - Correlation between neutrophil gelatinase-associated lipocalin and soluble CD14 
      subtype on the prognosis evaluation of acute paraquat poisoning patients.
PG  - 402-410
LID - 10.1177/0960327119897111 [doi]
AB  - OBJECTIVE: The objective of this article is to study the correlation between 
      neutrophil gelatinase-associated lipocalin (NGAL) and soluble CD14 subtype 
      (presepsin) on the severity and prognosis evaluation of acute paraquat poisoning 
      (APP) patients. MATERIALS AND METHODS: We studied 120 APP patients who were 
      divided into three groups: light (28 cases), moderate (52 cases), and heavy 
      poisoning (40 cases) groups. Twenty healthy volunteers were enrolled as controls. 
      RESULTS: Acute kidney injury (AKI) occurred in 86 APP patients (71.7%, 86 of 
      120). In AKI group, urine NGAL was elevated 3 h after treatment, serum NGAL was 
      elevated 24 h after treatment, and serum creatine (SCr) was elevated 2 days after 
      treatment, which were all significantly higher than non-AKI group. Compared with 
      control group, there were significant differences in presepsin and acute 
      physiology and chronic health status (APACHE) II score of different poisoning 
      groups. There were significant differences in detection indices 24 h, 3 days, and 
      7 days after treatment among different poisoning groups. There was a positive 
      correlation between urine NGAL and serum paraquat concentration, urine NGAL, and 
      AKI morbidity (r (1) = 0.974, r (2) = 0.766, p < 0.001), suggesting higher urine 
      NGAL level indicated higher AKI morbidity. Receiver operating characteristic 
      curves analysis suggested serum presepsin level and urine NGAL level had higher 
      sensitivity and specificity than APACHE II score when predicting 28-day mortality 
      of APP patients. CONCLUSION: Serum and urine NGAL level is elevated earlier than 
      SCr, which is important for the early diagnosis of APP. Serum presepsin and urine 
      NGAL levels can be used as markers to diagnose the severity of AKI and predict 
      the mortality of APP patients.
FAU - Gao, X
AU  - Gao X
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
AD  - Both the authors contributed equally to this work.
FAU - Wang, W-Z
AU  - Wang WZ
AUID- ORCID: 0000-0001-5405-2402
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
AD  - Both the authors contributed equally to this work.
FAU - Xiao, Q-M
AU  - Xiao QM
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
FAU - Qi, H-N
AU  - Qi HN
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
FAU - Zhu, B-Y
AU  - Zhu BY
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
FAU - Li, B-Y
AU  - Li BY
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
FAU - Wang, P
AU  - Wang P
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
FAU - Han, Y-Y
AU  - Han YY
AD  - Department of Emergency, Harrison International Peace Hospital Affiliated to 
      Hebei Medical University, Hebei, China.
LA  - eng
PT  - Journal Article
DEP - 20200120
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Peptide Fragments)
RN  - 0 (presepsin protein, human)
RN  - MU72812GK0 (Creatine)
RN  - PLG39H7695 (Paraquat)
SB  - IM
MH  - APACHE
MH  - Acute Kidney Injury/blood/*chemically induced/urine
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Creatine/blood
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - *Lipocalin-2/blood/urine
MH  - Lipopolysaccharide Receptors/*blood
MH  - Middle Aged
MH  - Paraquat/blood/*poisoning
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Time Factors
MH  - Young Adult
OTO - NOTNLM
OT  - APACHE II score
OT  - Acute paraquat poisoning
OT  - acute kidney injury
OT  - neutrophil gelatinase-associated lipocalin
OT  - soluble CD14 subtype
EDAT- 2020/01/21 06:00
MHDA- 2020/11/03 06:00
CRDT- 2020/01/21 06:00
PHST- 2020/01/21 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2020/01/21 06:00 [entrez]
AID - 10.1177/0960327119897111 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2020 Apr;39(4):402-410. doi: 10.1177/0960327119897111. Epub 2020 
      Jan 20.