PMID- 31959269
OWN - NLM
STAT- MEDLINE
DCOM- 20210427
LR  - 20210427
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Linking)
VI  - 33
IP  - 1
DP  - 2021 Feb
TI  - Childhood trauma and cognitive functioning in individuals at clinical high risk 
      (CHR) for psychosis.
PG  - 53-64
LID - 10.1017/S095457941900155X [doi]
AB  - Evidence suggests that early trauma may have a negative effect on cognitive 
      functioning in individuals with psychosis, yet the relationship between childhood 
      trauma and cognition among those at clinical high risk (CHR) for psychosis 
      remains unexplored. Our sample consisted of 626 CHR children and 279 healthy 
      controls who were recruited as part of the North American Prodrome Longitudinal 
      Study 2. Childhood trauma up to the age of 16 (psychological, physical, and 
      sexual abuse, emotional neglect, and bullying) was assessed by using the 
      Childhood Trauma and Abuse Scale. Multiple domains of cognition were measured at 
      baseline and at the time of psychosis conversion, using standardized assessments. 
      In the CHR group, there was a trend for better performance in individuals who 
      reported a history of multiple types of childhood trauma compared with those with 
      no/one type of trauma (Cohen d = 0.16). A history of multiple trauma types was 
      not associated with greater cognitive change in CHR converters over time. Our 
      findings tentatively suggest there may be different mechanisms that lead to CHR 
      states. Individuals who are at clinical high risk who have experienced multiple 
      types of childhood trauma may have more typically developing premorbid cognitive 
      functioning than those who reported minimal trauma do. Further research is needed 
      to unravel the complexity of factors underlying the development of at-risk 
      states.
FAU - Velikonja, T
AU  - Velikonja T
AUID- ORCID: 0000-0001-5675-3325
AD  - Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, 
      USA.
AD  - Seaver Center of Research and Treatment, Icahn School of Medicine, Mount Sinai, 
      New York, NY, USA.
FAU - Velthorst, E
AU  - Velthorst E
AD  - Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, 
      USA.
AD  - Seaver Center of Research and Treatment, Icahn School of Medicine, Mount Sinai, 
      New York, NY, USA.
FAU - Zinberg, J
AU  - Zinberg J
AD  - Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel 
      Institute for Neuroscience and Human Behavior, University of California-Los 
      Angeles, Los Angeles, CA, USA.
FAU - Cannon, T D
AU  - Cannon TD
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - Cornblatt, B A
AU  - Cornblatt BA
AD  - Department of Psychiatry, Zucker Hillside Hospital, Queens, NY, USA.
FAU - Perkins, D O
AU  - Perkins DO
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
FAU - Cadenhead, K S
AU  - Cadenhead KS
AD  - Department of Psychiatry, University of California-San Diego, La Jolla, CA, USA.
FAU - Tsuang, M T
AU  - Tsuang MT
AD  - Department of Psychiatry, University of California-San Diego, La Jolla, CA, USA.
FAU - Addington, J
AU  - Addington J
AD  - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, 
      Calgary, Alberta, Canada.
FAU - Woods, S W
AU  - Woods SW
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - McGlashan, T
AU  - McGlashan T
AD  - Department of Psychiatry, Yale University, New Haven, CT, USA.
FAU - Mathalon, D H
AU  - Mathalon DH
AD  - Department of Psychiatry, University of California-San Francisco, San Francisco, 
      CA, USA.
FAU - Stone, W
AU  - Stone W
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center, Boston, MA, USA.
FAU - Keshavan, M
AU  - Keshavan M
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center, Boston, MA, USA.
FAU - Seidman, L
AU  - Seidman L
AD  - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical 
      Center, Boston, MA, USA.
FAU - Bearden, C E
AU  - Bearden CE
AD  - Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel 
      Institute for Neuroscience and Human Behavior, University of California-Los 
      Angeles, Los Angeles, CA, USA.
LA  - eng
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - P50 MH080272/MH/NIMH NIH HHS/United States
GR  - R01 MH060720/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - K24 MH076191/MH/NIMH NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - P50 MH066286/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
SB  - IM
MH  - *Bullying
MH  - Child
MH  - Cognition
MH  - Humans
MH  - Longitudinal Studies
MH  - Prodromal Symptoms
MH  - *Psychotic Disorders
OTO - NOTNLM
OT  - childhood trauma
OT  - clinical high risk
OT  - nonsocial cognition
OT  - psychosis
OT  - social cognition
EDAT- 2020/01/22 06:00
MHDA- 2021/04/28 06:00
CRDT- 2020/01/22 06:00
PHST- 2020/01/22 06:00 [pubmed]
PHST- 2021/04/28 06:00 [medline]
PHST- 2020/01/22 06:00 [entrez]
AID - S095457941900155X [pii]
AID - 10.1017/S095457941900155X [doi]
PST - ppublish
SO  - Dev Psychopathol. 2021 Feb;33(1):53-64. doi: 10.1017/S095457941900155X.