PMID- 31960166
OWN - NLM
STAT- MEDLINE
DCOM- 20210721
LR  - 20210721
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 198
IP  - 2
DP  - 2020 Apr
TI  - Resveratrol Attenuates Intermittent Hypoxia-Induced Lung Injury by Activating the 
      Nrf2/ARE Pathway.
PG  - 323-331
LID - 10.1007/s00408-020-00321-w [doi]
AB  - PURPOSE: Obstructive sleep apnea (OSA) is associated with lung injury. As a novel 
      pathophysiological hallmark of OSA, chronic intermittent hypoxia (CIH) enhances 
      apoptosis. The present study aims to evaluate the effect of resveratrol (Res) on 
      CIH-induced lung apoptosis and inflammation in a rat model of CIH. METHODS: Rats 
      were randomly allocated to normoxia (control), CIH, and CIH + Res groups (n = 10 
      in each group). The CIH exposure duration was 12 weeks. Rats in the CIH + Res 
      group were additionally administered Res (50 mg kg(-1) d(-1)). Inflammatory 
      cytokine levels were detected by enzyme-linked immunosorbent assays (ELISAs). A 
      terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay was 
      conducted to evaluate the apoptosis rate. Bax, cleaved caspase-3, Nrf2 and HO-1 
      protein levels were detected by western blotting. RESULTS: The IL-6 and TNF-alpha 
      levels in the serum and alveolar lavage fluid in the CIH group were markedly 
      higher than those in the control group. The percentage of apoptotic cells in the 
      CIH group was higher than that in the control group. Bax and cleaved caspase-3 
      protein levels were increased in the CIH group compared with those in the control 
      group. Nrf2 and HO-1 protein levels were decreased in the CIH group compared with 
      those in the control group (p < 0.05). Compared with the CIH group, rats in the 
      CIH + Res group had lower percentages of apoptotic cells, lower IL-6, TNF-alpha, Bax 
      and cleaved caspase-3 protein levels, and higher Nrf2 and HO-1 protein levels 
      (p < 0.05). CONCLUSION: Res attenuates CIH-related inflammatory reactions and 
      apoptosis in lung tissue by activating the Nrf2/ARE pathway.
FAU - Lian, Ningfang
AU  - Lian N
AUID- ORCID: 0000-0002-6928-4342
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Fujian Medical University, Fuzhou, 350005, Fujian, China.
FAU - Zhang, Shuyi
AU  - Zhang S
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Fujian Medical University, Fuzhou, 350005, Fujian, China.
FAU - Huang, Jiefeng
AU  - Huang J
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Fujian Medical University, Fuzhou, 350005, Fujian, China.
FAU - Lin, Ting
AU  - Lin T
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Fujian Medical University, Fuzhou, 350005, Fujian, China.
FAU - Lin, Qichang
AU  - Lin Q
AD  - Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital 
      of Fujian Medical University, Fuzhou, 350005, Fujian, China. linqc_fy@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200120
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Bax protein, rat)
RN  - 0 (Il6 protein, rat)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Nfe2l2 protein, rat)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (bcl-2-Associated X Protein)
RN  - EC 1.14.14.18 (Heme Oxygenase (Decyclizing))
RN  - EC 1.14.14.18 (Hmox1 protein, rat)
RN  - EC 3.4.22.- (Casp3 protein, rat)
RN  - EC 3.4.22.- (Caspase 3)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - *Antioxidant Response Elements
MH  - Apoptosis/*drug effects
MH  - Caspase 3/metabolism
MH  - Disease Models, Animal
MH  - Heme Oxygenase (Decyclizing)
MH  - Hypoxia/*complications/metabolism
MH  - Inflammation Mediators/metabolism
MH  - Interleukin-6/metabolism
MH  - Lung/*drug effects/metabolism/pathology
MH  - Lung Injury/etiology/metabolism/pathology/*prevention & control
MH  - Male
MH  - NF-E2-Related Factor 2/*metabolism
MH  - Rats, Sprague-Dawley
MH  - Resveratrol/*pharmacology
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - bcl-2-Associated X Protein/metabolism
OTO - NOTNLM
OT  - Apoptosis
OT  - Intermittent hypoxia
OT  - Lung injury
OT  - Nrf2
OT  - Resveratrol
EDAT- 2020/01/22 06:00
MHDA- 2021/07/22 06:00
CRDT- 2020/01/22 06:00
PHST- 2019/10/01 00:00 [received]
PHST- 2020/01/02 00:00 [accepted]
PHST- 2020/01/22 06:00 [pubmed]
PHST- 2021/07/22 06:00 [medline]
PHST- 2020/01/22 06:00 [entrez]
AID - 10.1007/s00408-020-00321-w [pii]
AID - 10.1007/s00408-020-00321-w [doi]
PST - ppublish
SO  - Lung. 2020 Apr;198(2):323-331. doi: 10.1007/s00408-020-00321-w. Epub 2020 Jan 20.