PMID- 31962170
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-2763 (Electronic)
IS  - 1873-2763 (Linking)
VI  - 133
DP  - 2020 Apr
TI  - Subchondral bone dysplasia partly participates in prenatal dexamethasone 
      induced-osteoarthritis susceptibility in female offspring rats.
PG  - 115245
LID - S8756-3282(20)30025-9 [pii]
LID - 10.1016/j.bone.2020.115245 [doi]
AB  - Prenatal dexamethasone exposure (PDE) induces developmental toxicities of 
      multi-organs and susceptibility to multi-diseases in offspring. However, the 
      effects of PDE on osteoarthritis susceptibility in adult offspring and its 
      mechanism have not been reported. In the present study, we treated pregnant 
      Wistar rats with dexamethasone (0.2 mg/kg) daily on gestational days (GD) 9-20. 
      Some pregnant rats were sacrificed on GD20, and the rest were delivered to obtain 
      the postnatal offspring. The adult female offspring rats were performed with 
      ovariectomy or sham operation during postnatal weeks 22-28. We found that PDE led 
      to osteoarthritis phenotypes in articular cartilage and an increase in modified 
      Mankin's score, but reduced the cartilage thickness in female adult offspring 
      rats, which were more evident after ovariectomy. Moreover, PDE reduced the bone 
      mass of subchondral bone in female adult offspring, which was aggravated by 
      ovariectomy. The correlation analysis results indicated that the osteoarthritic 
      phenotype and cartilage thickness were closely associated with the decreased bone 
      mass of subchondral bone induced by PDE. Further, PDE retarded the development of 
      primary and secondary ossification centers, then led to subchondral bone 
      dysplasia, which could be partly mediated by the inhibited osteogenic function 
      before and after birth. Collectively, the subchondral bone dysplasia partly 
      participated in osteoarthritis susceptibility induced by PDE in female offspring 
      rats.
CI  - Copyright (c) 2020. Published by Elsevier Inc.
FAU - Xiao, Hao
AU  - Xiao H
AD  - Department of Orthopedic Surgery, Wuhan University Zhongnan Hospital, Wuhan 
      430071, China.
FAU - Xie, Xingkui
AU  - Xie X
AD  - Department of Orthopedic Surgery, Wuhan University Zhongnan Hospital, Wuhan 
      430071, China.
FAU - Wen, Yinxian
AU  - Wen Y
AD  - Department of Orthopedic Surgery, Wuhan University Zhongnan Hospital, Wuhan 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan 430071, China.
FAU - Tan, Yang
AU  - Tan Y
AD  - Department of Orthopedic Surgery, Wuhan University Zhongnan Hospital, Wuhan 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan 430071, China.
FAU - Shangguan, Yangfan
AU  - Shangguan Y
AD  - Department of Orthopedic Surgery, Wuhan University Zhongnan Hospital, Wuhan 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan 430071, China.
FAU - Li, Bin
AU  - Li B
AD  - Department of Orthopedic Surgery, Wuhan University Zhongnan Hospital, Wuhan 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan 430071, China.
FAU - Magdalou, Jacques
AU  - Magdalou J
AD  - UMR 7365 CNRS, University of Lorraine, Nancy 54000, France.
FAU - Wang, Hui
AU  - Wang H
AD  - Department of Pharmacology, Wuhan University School of Basic Medical Sciences, 
      Wuhan 430071, China; Hubei Provincial Key Laboratory of Developmentally 
      Originated Disease, Wuhan 430071, China.
FAU - Chen, Liaobin
AU  - Chen L
AD  - Department of Orthopedic Surgery, Wuhan University Zhongnan Hospital, Wuhan 
      430071, China; Hubei Provincial Key Laboratory of Developmentally Originated 
      Disease, Wuhan 430071, China. Electronic address: lbchen@whu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200118
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Animals
MH  - *Bone Diseases, Developmental
MH  - *Cartilage, Articular
MH  - Dexamethasone/toxicity
MH  - Female
MH  - *Osteoarthritis/chemically induced
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Dexamethasone
OT  - Intrauterine programming
OT  - Osteoarthritis
OT  - Osteogenic differentiation
OT  - Subchondral bone dysplasia
COIS- Declaration of competing interest All of the authors state that they have no 
      conflicts of interest.
EDAT- 2020/01/22 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/01/22 06:00
PHST- 2019/11/27 00:00 [received]
PHST- 2020/01/07 00:00 [revised]
PHST- 2020/01/17 00:00 [accepted]
PHST- 2020/01/22 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/01/22 06:00 [entrez]
AID - S8756-3282(20)30025-9 [pii]
AID - 10.1016/j.bone.2020.115245 [doi]
PST - ppublish
SO  - Bone. 2020 Apr;133:115245. doi: 10.1016/j.bone.2020.115245. Epub 2020 Jan 18.