PMID- 31963577
OWN - NLM
STAT- MEDLINE
DCOM- 20200819
LR  - 20200819
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 2
DP  - 2020 Jan 17
TI  - Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and 
      Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal 
      Women.
LID - 10.3390/ijerph17020606 [doi]
LID - 606
AB  - There are little epidemiological data on the impact of persistent organic 
      pollutants (POPs) and endocrine disruptors on mammographic density (MD), a strong 
      predictor of breast cancer. We assessed MD in 116 non-Hispanic white 
      post-menopausal women for whom serum concentrations of 23 commonly detected 
      chemicals including 3 polybrominated diphenyl ethers (PBDEs), 8 per- and 
      polyfluoroalkyl substances (PFASs), and 12 polychlorinated biphenyls (PCBs) had 
      been measured. Linear regression analyses adjusting for potential confounders 
      were used to examine the associations between the levels of the chemical 
      compounds, modeled as continuous and dichotomized (above/below median) variables, 
      and square-root-transformed MD. None of the associations were statistically 
      significant after correcting for multiple testing. Prior to correction for 
      multiple testing, all chemicals with un-corrected p-values < 0.05 had regression 
      coefficients less than zero, suggesting inverse associations between increased 
      levels and MD, if any. The smallest p-value was observed for PCB-153 (regression 
      coefficient for above-median vs. below-median levels: -0.87, un-corrected p = 
      0.008). Neither parity nor body mass index modified the associations. Our results 
      do not support an association between higher MD and serum levels of PBDEs, PCBs, 
      or PFASs commonly detected in postmenopausal women.
FAU - Lee, Eunjung
AU  - Lee E
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
FAU - Kinninger, April
AU  - Kinninger A
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
FAU - Ursin, Giske
AU  - Ursin G
AD  - Cancer Registry of Norway, 0304 Oslo, Norway.
AD  - Department of Nutrition, University of Oslo, 0304 Oslo, Norway.
FAU - Tseng, Chiuchen
AU  - Tseng C
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
FAU - Hurley, Susan
AU  - Hurley S
AD  - Department of Epidemiology and Biostatistics, University of California San 
      Francisco, San Francisco, CA 94704, USA.
FAU - Wang, Miaomiao
AU  - Wang M
AD  - Environmental Chemistry Laboratory, Department of Toxic Substances Control, 
      Berkeley, CA 94710, USA.
FAU - Wang, Yunzhu
AU  - Wang Y
AD  - Environmental Chemistry Laboratory, Department of Toxic Substances Control, 
      Berkeley, CA 94710, USA.
FAU - Park, June-Soo
AU  - Park JS
AD  - Environmental Chemistry Laboratory, Department of Toxic Substances Control, 
      Berkeley, CA 94710, USA.
FAU - Petreas, Myrto
AU  - Petreas M
AD  - Environmental Chemistry Laboratory, Department of Toxic Substances Control, 
      Berkeley, CA 94710, USA.
FAU - Deapen, Dennis
AU  - Deapen D
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
FAU - Reynolds, Peggy
AU  - Reynolds P
AD  - Department of Epidemiology and Biostatistics, University of California San 
      Francisco, San Francisco, CA 94704, USA.
LA  - eng
GR  - P30 ES007048/ES/NIEHS NIH HHS/United States
GR  - P30-CA033572/CA/NCI NIH HHS/United States
GR  - R01-CA077398/CA/NCI NIH HHS/United States
GR  - P30-CA023100/CA/NCI NIH HHS/United States
GR  - U01-CA199277/CA/NCI NIH HHS/United States
GR  - UM1-CA164917/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200117
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fluorocarbons)
RN  - 0 (Halogenated Diphenyl Ethers)
SB  - IM
MH  - Aged
MH  - *Breast Density
MH  - California
MH  - Environmental Pollutants/*blood
MH  - Fluorocarbons/*blood
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Middle Aged
MH  - *Postmenopause
PMC - PMC7013395
OTO - NOTNLM
OT  - mammographic density
OT  - per- and polyfluoroalkyl substances
OT  - persistent organic pollutants
OT  - polybrominated diphenyl ethers
OT  - polychlorinated biphenyls
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/01/23 06:00
MHDA- 2020/08/20 06:00
PMCR- 2020/01/01
CRDT- 2020/01/23 06:00
PHST- 2019/12/12 00:00 [received]
PHST- 2020/01/11 00:00 [revised]
PHST- 2020/01/12 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2020/01/23 06:00 [pubmed]
PHST- 2020/08/20 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - ijerph17020606 [pii]
AID - ijerph-17-00606 [pii]
AID - 10.3390/ijerph17020606 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2020 Jan 17;17(2):606. doi: 
      10.3390/ijerph17020606.