PMID- 31964558
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 218
DP  - 2020 Apr
TI  - Depressive symptoms during first episode psychosis and functional outcome: A 
      systematic review and meta-analysis.
PG  - 14-27
LID - S0920-9964(19)30581-X [pii]
LID - 10.1016/j.schres.2019.12.011 [doi]
AB  - OBJECTIVES: First episode psychosis (FEP) is associated with functional decline. 
      Existing evidence was synthesised to explore the influence of depressive symptoms 
      during FEP on future social, occupational and global functioning. METHODS: 
      Medline, Embase, PsychINFO, Cochrane Library, Open Grey, NICE Evidence and Web of 
      Science were searched from inception to May 2018. Longitudinal studies of FEP 
      patients were included. Study quality was assessed using the Downs and Black 
      instrument. Two meta-analyses were performed using random effect models. The 
      first meta-analysis correlates depressive symptoms during FEP with follow-up 
      Global Assessment of Functioning (GAF) scores. The second meta-analysis shows the 
      odds of long-term functional remission if depressive symptoms are present during 
      FEP. RESULTS: 4751 unique abstracts were found. 36 articles were included. The 
      first meta-analysis included 7 studies (932 participants) and showed depressive 
      symptoms during FEP were negatively correlated with follow-up GAF scores 
      (r = -0.16, 95% CI: -0.24 to -0.09, p < 0.001). The second meta-analysis of 9 
      studies (2265 participants) showed weak evidence of an association between the 
      presence of depressive symptoms in FEP and reduction in functional remission 
      (OR = 0.87, 95% CI: 0.68 to 1.13, p = 0.294). CONCLUSION: Depressive symptoms 
      during FEP are associated with poorer long-term global functioning and may be 
      associated with a reduced chance of achieving functional remission. Clinical 
      trials are needed to identify efficacious management of depressive symptoms in 
      early psychosis.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - McGinty, Jessica
AU  - McGinty J
AD  - University of Birmingham, College of Medical and Dental Sciences, Birmingham, 
      United Kingdom.
FAU - Upthegrove, Rachel
AU  - Upthegrove R
AD  - University of Birmingham, College of Medical and Dental Sciences, Birmingham, 
      United Kingdom; University of Birmingham, Institute for Mental Health, 
      Birmingham, United Kingdom; Early Intervention Service, Birmingham Womens and 
      Childrens NHS Trust, Birmingham, United Kingdom. Electronic address: 
      r.upthegrove@bham.ac.uk.
LA  - eng
GR  - NIHR127700/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200120
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - *Depression
MH  - Humans
MH  - Longitudinal Studies
MH  - *Psychotic Disorders/complications
OTO - NOTNLM
OT  - Depression
OT  - First episode
OT  - Functioning
OT  - Meta-analysis
OT  - Psychoses
COIS- Declaration of competing interest We declare no competing interests.
EDAT- 2020/01/23 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/01/23 06:00
PHST- 2019/02/16 00:00 [received]
PHST- 2019/12/17 00:00 [revised]
PHST- 2019/12/17 00:00 [accepted]
PHST- 2020/01/23 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/01/23 06:00 [entrez]
AID - S0920-9964(19)30581-X [pii]
AID - 10.1016/j.schres.2019.12.011 [doi]
PST - ppublish
SO  - Schizophr Res. 2020 Apr;218:14-27. doi: 10.1016/j.schres.2019.12.011. Epub 2020 
      Jan 20.