PMID- 31965512 OWN - NLM STAT- MEDLINE DCOM- 20210721 LR - 20220127 IS - 1868-601X (Electronic) IS - 1868-4483 (Linking) VI - 11 IP - 4 DP - 2020 Aug TI - The Association Between Serum Apelin-13 and the Prognosis of Acute Ischemic Stroke. PG - 700-707 LID - 10.1007/s12975-019-00769-w [doi] AB - While a number of studies have reported an association between apelin-13 and ischemic stroke, few have verified its clinical effect. We investigated the prognostic value of serum apelin-13 levels in patients with acute ischemic stroke (AIS). We prospectively recruited 244 AIS patients within 24 h after stroke onset, and 167 healthy controls. We assessed the serum apelin-13 levels using ELISA, and the severity of AIS using the National Institutes of Health Stroke Scale (NIHSS). The primary outcomes included death or major disability (modified Rankin Scale score, 3-6) and major disability (modified Rankin Scale score, 3-5). Secondary outcomes included recurrent stroke and combined events (all-cause death, or cardiovascular and cerebrovascular events). We found that the serum apelin-13 levels in the patients (38.63 ng/mL (interquartile range [IQR], 29.86-50.99)) were lower than those in the healthy controls (42.50 ng/mL [IQR, 31.25-59.17]) (P = 0.017). Patients with a NIHSS score 3 (P = 0.048). At the 3-month follow-up, multivariate logistic regression analysis indicated an association between apelin-13 and death or major disability (OR 0.31; 95% CI 0.11-0.86; P = 0.024) and major disability (OR 0.32; 95% CI 0.11-0.90; P = 0.030). At the 1-year follow-up, the patients with high apelin-13 levels showed a lower incidence of stroke and combined events (Log-rank test P < 0.05). Our findings indicate that serum apelin-13 may be a potential prognostic biomarker for AIS. FAU - Wang, Xiao AU - Wang X AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Tian, Xuan AU - Tian X AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Pei, Lu-Lu AU - Pei LL AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Niu, Peng-Peng AU - Niu PP AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Guo, Yinan AU - Guo Y AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Hu, Ruiyao AU - Hu R AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Liu, Kai AU - Liu K AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Tian, Mengke AU - Tian M AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Li, Youfeng AU - Li Y AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Wang, Chunhui AU - Wang C AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Wang, Xin AU - Wang X AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. FAU - Xu, Yuming AU - Xu Y AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. xuyuming@zzu.edu.cn. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. xuyuming@zzu.edu.cn. FAU - Song, Bo AU - Song B AD - Department of Neurology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou, 450052, Henan, China. fccsongb@zzu.edu.cn. AD - Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, 450052, China. fccsongb@zzu.edu.cn. LA - eng GR - 81571158/National Natural Science Foundation of China (CN)/International GR - 16A320054/Education Department of Henan Province/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200122 PL - United States TA - Transl Stroke Res JT - Translational stroke research JID - 101517297 RN - 0 (APLN protein, human) RN - 0 (Apelin) SB - IM MH - Aged MH - Apelin/*blood MH - Brain Ischemia/*blood/*diagnosis MH - Female MH - Humans MH - Ischemic Stroke/*blood/*diagnosis MH - Kaplan-Meier Estimate MH - Male MH - Middle Aged MH - Prognosis MH - Prospective Studies MH - Sensitivity and Specificity OTO - NOTNLM OT - Acute ischemic stroke OT - Biomarker OT - Prognosis OT - Serum apelin-13 EDAT- 2020/01/23 06:00 MHDA- 2021/07/22 06:00 CRDT- 2020/01/23 06:00 PHST- 2019/10/10 00:00 [received] PHST- 2019/12/05 00:00 [accepted] PHST- 2019/12/03 00:00 [revised] PHST- 2020/01/23 06:00 [pubmed] PHST- 2021/07/22 06:00 [medline] PHST- 2020/01/23 06:00 [entrez] AID - 10.1007/s12975-019-00769-w [pii] AID - 10.1007/s12975-019-00769-w [doi] PST - ppublish SO - Transl Stroke Res. 2020 Aug;11(4):700-707. doi: 10.1007/s12975-019-00769-w. Epub 2020 Jan 22.