PMID- 31965560
OWN - NLM
STAT- MEDLINE
DCOM- 20210413
LR  - 20210413
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 35
IP  - 7
DP  - 2020 Jul
TI  - Chaperone-mediated autophagy in cancer: Advances from bench to bedside.
PG  - 637-644
LID - 10.14670/HH-18-202 [doi]
AB  - Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular 
      proteins with KFERQ-like motif are targeted to the lysosome for degradation, is 
      necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative 
      diseases has been extensively studied in the past decades, with defects in the 
      pathway being strongly associated with disease. Recently, accumulating evidence 
      has demonstrated a consistent increase in basal CMA activity in a wide array of 
      cancer cell lines and human tumor biopsies, suggesting a potential link between 
      CMA and cancer. On the other hand, an anti-oncogenic role for CMA under 
      physiological conditions in non-transformed cells is also proposed despite the 
      pro-tumorigenic function of CMA in cancer cells. The growing number of 
      connections between CMA and cancers has generated interest in modulating CMA 
      activity for therapeutic purposes. Here, we describe recent advances in the 
      understanding of the molecular regulation of CMA, and discuss the evidence in 
      support of the contribution of CMA dysfunction to cancers.
FAU - Hou, Tao
AU  - Hou T
AD  - Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Fan, Yizeng
AU  - Fan Y
AD  - Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Dan, Weichao
AU  - Dan W
AD  - Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Liu, Bo
AU  - Liu B
AD  - Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Wang, Zixi
AU  - Wang Z
AD  - Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China.
FAU - Zeng, Jin
AU  - Zeng J
AD  - Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China. zengjin1984@gmail.com.
FAU - Li, Lei
AU  - Li L
AD  - Department of Urology, the First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, China. lilydr@163.com.
LA  - eng
GR  - 81773206/National Natural Science Foundation of China/
GR  - 81925028/National Natural Science Foundation of China/
GR  - 81672538/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20200122
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
SB  - IM
MH  - Animals
MH  - Chaperone-Mediated Autophagy/*physiology
MH  - Humans
MH  - Neoplasms/*pathology
EDAT- 2020/01/23 06:00
MHDA- 2021/04/14 06:00
CRDT- 2020/01/23 06:00
PHST- 2020/01/23 06:00 [pubmed]
PHST- 2021/04/14 06:00 [medline]
PHST- 2020/01/23 06:00 [entrez]
AID - HH-18-202 [pii]
AID - 10.14670/HH-18-202 [doi]
PST - ppublish
SO  - Histol Histopathol. 2020 Jul;35(7):637-644. doi: 10.14670/HH-18-202. Epub 2020 
      Jan 22.