PMID- 31966030
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1662-6567 (Print)
IS  - 1662-6567 (Electronic)
IS  - 1662-6567 (Linking)
VI  - 11
IP  - 3
DP  - 2019 Sep-Dec
TI  - A Case of Salazosulfapyridine-Induced Hypersensitivity Syndrome in a Rheumatoid 
      Arthritis Patient with Relapse of Skin Erythema.
PG  - 334-337
LID - 10.1159/000504644 [doi]
AB  - We experienced a rare case of drug-induced hypersensitivity syndrome (DIHS) in 
      which salazosulfapyridine (SASP) reactivated human herpesvirus 6 (HHV-6) and 
      cytomegalovirus (CMV), which resulted in a relapse of skin symptoms after 
      changing to mizoribine. At the time of recurrence of skin erythema after the 
      initiation of mizoribine, the serum DNA titers of not HHV-6 but CMV were 
      elevated. A drug-induced lymphocyte stimulation test was negative for mizoribine 
      but positive for SASP. In this case, DIHS developed with SASP in association with 
      HHV-6 and CMV reactivation. The immunocompromised state induced by herpes virus 
      reactivation and mizoribine might have caused the relapse of skin erythema.
CI  - Copyright (c) 2019 by S. Karger AG, Basel.
FAU - Itoi-Ochi, Saori
AU  - Itoi-Ochi S
AD  - Department of Dermatology, Osaka University Graduate School of Medicine, Suita, 
      Japan.
FAU - Nakagawa, Yukinobu
AU  - Nakagawa Y
AD  - Department of Dermatology, Osaka University Graduate School of Medicine, Suita, 
      Japan.
FAU - Tanemura, Atsushi
AU  - Tanemura A
AD  - Department of Dermatology, Osaka University Graduate School of Medicine, Suita, 
      Japan.
FAU - Hirao, Makoto
AU  - Hirao M
AD  - Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 
      Suita, Japan.
FAU - Fujimoto, Manabu
AU  - Fujimoto M
AD  - Department of Dermatology, Osaka University Graduate School of Medicine, Suita, 
      Japan.
LA  - eng
PT  - Case Reports
DEP - 20191217
PL  - Switzerland
TA  - Case Rep Dermatol
JT  - Case reports in dermatology
JID - 101517685
PMC - PMC6959106
OTO - NOTNLM
OT  - Cytomegalovirus
OT  - Drug-induced hypersensitivity syndrome
OT  - Human herpesvirus 6
OT  - Relapse
OT  - Salazosulfapyridine
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/23 06:00
MHDA- 2020/01/23 06:01
PMCR- 2019/12/17
CRDT- 2020/01/23 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2019/11/02 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2020/01/23 06:00 [pubmed]
PHST- 2020/01/23 06:01 [medline]
PHST- 2019/12/17 00:00 [pmc-release]
AID - cde-0011-0334 [pii]
AID - 10.1159/000504644 [doi]
PST - epublish
SO  - Case Rep Dermatol. 2019 Dec 17;11(3):334-337. doi: 10.1159/000504644. eCollection 
      2019 Sep-Dec.