PMID- 31966050
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231113
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 19
IP  - 2
DP  - 2020 Feb
TI  - Effects of hub genes on the clinicopathological and prognostic features of lung 
      adenocarcinoma.
PG  - 1203-1214
LID - 10.3892/ol.2019.11193 [doi]
AB  - Lung adenocarcinoma (LUAD) is a common malignancy; however, the majority of its 
      underlying molecular mechanisms remain unknown. In the present study, weighted 
      gene co-expression network analysis was applied to construct gene co-expression 
      networks for the GSE19804 dataset, in order to screen hub genes associated with 
      the pathogenesis of LUAD. In addition, with the aid of the Database for 
      Annotation, Visualization and Integrated Discovery, Gene Ontology, and Kyoto 
      Encyclopedia of Genes and Genomes, pathway enrichment analyses were performed on 
      the genes in the selected module. Using the GSE40791 dataset and The Cancer 
      Genome Atlas database, the hub genes were identified. It was discovered that the 
      turquoise module was the most significant module associated with the tumor stage 
      of LUAD. After performing functional enrichment analyses, it was indicated that 
      the turquoise module was mainly enriched in signal transduction. Additionally, at 
      the transcriptional and translational level, nine hub genes were identified and 
      validated: Carbonic anhydrase 4 (CA4), platelet and endothelial cell adhesion 
      molecule 1 (PECAM1), DnaJ member B4 (DNAJB4), advanced glycosylation end-product 
      specific receptor (AGER), GTPase, IMAP family member 6 (GIMAP6), chromosome 10 
      open reading frame 54 (C10orf54), dedicator of cytokinesis 4 (DOCK4), Golgi 
      membrane protein 1 (GOLM1) and platelet activating factor acetylhydrolase 1b 
      catalytic subunit 3 (PAFAH1B3). CA4, PECAM1, DNAJB4, AGER, GIMAP6, C10orf54 and 
      DOCK4 were expressed at lower levels in the tumor samples, whereas GOLM1 and 
      PAFAH1B3 were highly expressed in tumor samples. In addition, all hub genes were 
      associated with prognosis. In conclusion, one module and nine genes were 
      recognized to be associated with the tumor stage of LUAD. These findings may 
      enhance the understanding of the progression and prognosis of LUAD.
CI  - Copyright: (c) Yu et al.
FAU - Yu, Dong-Hu
AU  - Yu DH
AD  - Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 
      Hubei 430071, P.R. China.
AD  - Department of Biological Repositories, Zhongnan Hospital of Wuhan University, 
      Wuhan, Hubei 430071, P.R. China.
FAU - Huang, Jing-Yu
AU  - Huang JY
AD  - Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Liu, Xiao-Ping
AU  - Liu XP
AD  - Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 
      430071, P.R. China.
FAU - Ruan, Xiao-Lan
AU  - Ruan XL
AD  - Department of Hematology, Renmin Hospital of Wuhan University, Wuhan, Hubei 
      430071, P.R. China.
FAU - Chen, Chen
AU  - Chen C
AD  - Department of Biological Repositories, Zhongnan Hospital of Wuhan University, 
      Wuhan, Hubei 430071, P.R. China.
AD  - Human Genetics Resource Preservation Center of Hubei Province, Wuhan, Hubei 
      430071, P.R. China.
FAU - Hu, Wei-Dong
AU  - Hu WD
AD  - Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 
      Hubei 430071, P.R. China.
FAU - Li, Sheng
AU  - Li S
AD  - Department of Biological Repositories, Zhongnan Hospital of Wuhan University, 
      Wuhan, Hubei 430071, P.R. China.
AD  - Human Genetics Resource Preservation Center of Hubei Province, Wuhan, Hubei 
      430071, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20191209
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6956410
OTO - NOTNLM
OT  - Gene Expression Omnibus
OT  - The Cancer Genome Atlas
OT  - clinical prognosis
OT  - hub genes
OT  - lung adenocarcinoma
OT  - weighted gene co-expression network analysis
EDAT- 2020/01/23 06:00
MHDA- 2020/01/23 06:01
PMCR- 2019/12/09
CRDT- 2020/01/23 06:00
PHST- 2019/05/04 00:00 [received]
PHST- 2019/11/07 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2020/01/23 06:00 [pubmed]
PHST- 2020/01/23 06:01 [medline]
PHST- 2019/12/09 00:00 [pmc-release]
AID - OL-0-0-11193 [pii]
AID - 10.3892/ol.2019.11193 [doi]
PST - ppublish
SO  - Oncol Lett. 2020 Feb;19(2):1203-1214. doi: 10.3892/ol.2019.11193. Epub 2019 Dec 
      9.