PMID- 31966378
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200126
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 10
IP  - 10
DP  - 2017
TI  - Artemin promotes proliferation and metastasis in human laryngeal squamous cell 
      carcinoma.
PG  - 10413-10418
AB  - Laryngeal squamous cell carcinoma (LSCC) is the main type of human laryngeal 
      cancer which is one of the most common malignant head and neck tumors and the 
      outcomes of LSCC patients are always poor. The intrinsic molecular mechanisms in 
      initiation, development, growth and metastasis of LSCC remain unclear. Further 
      researches are necessary and urgent. In this article, we examined artemin (ARTN) 
      promoted both cell proliferation and metastasis of human LSCC cells Hep-2 by 
      siRNA mediated ARTN knocking down using MTT assay, cell migration assay and cell 
      invasion assay. Moreover, we examined the expression level of ARTN in LSCC 
      tissues was much higher than that in benign laryngeal polyp tissues. In addition, 
      ARTN was identified as a direct target of miR-223 and miR-223 suppressed the 
      expression of ARTN in LSCC cells. Supplement to our former study, we demonstrated 
      ARTN was oncogenic both in vitro and in clinical tissues. As a result, ARTN could 
      be used as a potential therapeutic target for human LSCC.
CI  - IJCEP Copyright (c) 2017.
FAU - Gao, Chao-Bing
AU  - Gao CB
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of AnHui Medical University Hefei, Anhui, China.
FAU - Wang, Dong
AU  - Wang D
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of AnHui Medical University Hefei, Anhui, China.
FAU - Wang, Yang
AU  - Wang Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of AnHui Medical University Hefei, Anhui, China.
FAU - Liu, Ye-Hai
AU  - Liu YH
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of AnHui Medical University Hefei, Anhui, China.
LA  - eng
PT  - Journal Article
DEP - 20171001
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6965782
OTO - NOTNLM
OT  - Artemin
OT  - glioma
OT  - metastasis
OT  - miR-223
OT  - proliferation
COIS- None.
EDAT- 2017/10/01 00:00
MHDA- 2017/10/01 00:01
PMCR- 2017/10/01
CRDT- 2020/01/23 06:00
PHST- 2017/06/04 00:00 [received]
PHST- 2017/06/22 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2017/10/01 00:00 [pubmed]
PHST- 2017/10/01 00:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2017 Oct 1;10(10):10413-10418. eCollection 2017.