PMID- 31966391
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200126
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 10
IP  - 10
DP  - 2017
TI  - A rare and easily misdiagnosed tumor of the urinary bladder: primary composite 
      pheochromocytoma.
PG  - 10522-10530
AB  - BACKGROUND: Composite pheochromocytoma, which is a tumor composed of ordinary 
      pheochromocytoma and other components, is extremely rare in bladder. We present a 
      case of this rarely seen tumor in bladder, and discuss the clinical features, 
      behavior, pathologic findings, essentials of diagnosis and prognosis of this 
      tumor after literature review. METHODS: Specimens from a 55-year-old woman with 
      primary composite pheochromocytoma in bladder were analyzed by 
      immunohistochemical (IHC) and fluorescence in situ hybridization (FISH). 
      Clinicopathological characteristics were also collected and discussed. Then, we 
      searched and reviewed literatures related with composite pheochromocytoma that 
      were published in PubMed over the last 80 years. RESULTS: B-mode ultrasound 
      scanner and Magnetic Resonance Imaging (MRI) detected a papillary and 
      infiltrative tumor mass in the irregularly thickened posterior walls of the 
      urinary bladder. Histologically, the tumor showed evidence of big ganglion-liked 
      cells and small round cells in cystoscopy biopsy and typical "Zellballen" 
      structure in gross specimen. On PubMed, a total of 58 cases of composite 
      pheochromocytoma has been reported during 1933-2017. CONCLUSION: Composite 
      pheochromocytoma in urinary bladder, which has distinctive clincopathologic 
      features, is an extremely rare disease and can only be diagnosed by pathologists. 
      Diagnosis is difficult before histopathological examination and should be 
      considered in patients with no risk factors for usual bladder tumor. The rate of 
      metastasis and death is higher in cases where the second component is not 
      ganglioneuroma. Fortunately, treatment of this type of tumor remains the same as 
      pheochromocytoma. Patients with localized tumors have an extremely favorable 
      prognosis.
CI  - IJCEP Copyright (c) 2017.
FAU - Hu, Wanming
AU  - Hu W
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen 
      University Guangzhou, China.
AD  - Pathology, Cancer Center, Sun Yat-sen University Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine Guangdong, China.
FAU - Huang, Jinlin
AU  - Huang J
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen 
      University Guangzhou, China.
AD  - Pathology, Cancer Center, Sun Yat-sen University Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine Guangdong, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen 
      University Guangzhou, China.
AD  - Pathology, Cancer Center, Sun Yat-sen University Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine Guangdong, China.
FAU - Xi, Shaoyan
AU  - Xi S
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen 
      University Guangzhou, China.
AD  - Pathology, Cancer Center, Sun Yat-sen University Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine Guangdong, China.
FAU - Wu, Huiyu
AU  - Wu H
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen 
      University Guangzhou, China.
AD  - General, Cancer Center, Sun Yat-sen University Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine Guangdong, China.
FAU - Wu, Qiuliang
AU  - Wu Q
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen 
      University Guangzhou, China.
AD  - Pathology, Cancer Center, Sun Yat-sen University Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine Guangdong, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Pathology, Guangzhou General Hospital of Guangzhou Military Area 
      Command of Chinese PLA Guangzhou, China.
FAU - Zeng, Jing
AU  - Zeng J
AD  - State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen 
      University Guangzhou, China.
AD  - Pathology, Cancer Center, Sun Yat-sen University Guangzhou, China.
AD  - Collaborative Innovation Center for Cancer Medicine Guangdong, China.
LA  - eng
PT  - Case Reports
DEP - 20171001
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6965767
OTO - NOTNLM
OT  - Composite pheochromocytoma
OT  - FISH
OT  - IHC
OT  - bladder
OT  - diagnosis
OT  - ganglioneuroma
OT  - primary
COIS- None.
EDAT- 2017/10/01 00:00
MHDA- 2017/10/01 00:01
PMCR- 2017/10/01
CRDT- 2020/01/23 06:00
PHST- 2017/07/09 00:00 [received]
PHST- 2017/09/08 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2017/10/01 00:00 [pubmed]
PHST- 2017/10/01 00:01 [medline]
PHST- 2017/10/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2017 Oct 1;10(10):10522-10530. eCollection 2017.