PMID- 31966527
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200126
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 10
IP  - 12
DP  - 2017
TI  - Dynamaic changes of proliferation and apoptosis in rat retina development.
PG  - 11679-11684
AB  - Precise coordination of cell proliferation and apoptosis is essential for proper 
      organ morphogenesis and function during mammalian development. The retina is a 
      part of the central nervous system, with a function in capture and conversion of 
      light particles into nerve signals. However, the dynamical changes of cell 
      proliferation and apoptosis during the retinal development is unclear. Thus, this 
      study was to observe the changes of proliferating cell nuclear antigen expression 
      and apoptosis during the retina development in rats. Rats from different 
      developmental stages (embryonic days 14-20 (E14-20), postnatal days 0-15 (P0-15) 
      and adult (P36)) were used. The eyeballs were removed and fixed immediately in 
      formalin. The tissues were embedded in paraffin. Sections were prepared for 
      immunohistochemical staining and terminal deoxynucleotidyl transferase-mediated 
      dUTP nick end labeling (TUNEL). PCNA expression appeared in large quantities in 
      rat retina from E14 to P7, decreased obviously since P9, and could not be 
      observed since P15. Apoptotic cells appeared in small quantities since E18. And 
      then apoptotic cells dramatically increased during the retina development, and 
      peaked at P7. As maturation continued, these cells decreased gradually. Apoptotic 
      cells could not be found in the mature retina. Cell proliferation and apoptosis 
      shows orderly and dynamic changes during the retina development, which is 
      essential for the development of normal structure and function of the retina.
CI  - IJCEP Copyright (c) 2017.
FAU - Shi, Weibo
AU  - Shi W
AD  - Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory 
      of Forensic Medicine, Collaborative Innovation Center of Forensic Medical 
      Molecular Identification Shijiazhuang, China.
FAU - Wang, Ran
AU  - Wang R
AD  - Department of Psychiatry, The First Hospital of Hebei Medical University 
      Shijiazhuang, China.
FAU - Niu, Shiba
AU  - Niu S
AD  - Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory 
      of Forensic Medicine, Collaborative Innovation Center of Forensic Medical 
      Molecular Identification Shijiazhuang, China.
FAU - Li, Yingmin
AU  - Li Y
AD  - Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory 
      of Forensic Medicine, Collaborative Innovation Center of Forensic Medical 
      Molecular Identification Shijiazhuang, China.
FAU - Ma, Chunling
AU  - Ma C
AD  - Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory 
      of Forensic Medicine, Collaborative Innovation Center of Forensic Medical 
      Molecular Identification Shijiazhuang, China.
FAU - Zhang, Guozhong
AU  - Zhang G
AD  - Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory 
      of Forensic Medicine, Collaborative Innovation Center of Forensic Medical 
      Molecular Identification Shijiazhuang, China.
FAU - Cong, Bin
AU  - Cong B
AD  - Department of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory 
      of Forensic Medicine, Collaborative Innovation Center of Forensic Medical 
      Molecular Identification Shijiazhuang, China.
LA  - eng
PT  - Journal Article
DEP - 20171201
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6966058
OTO - NOTNLM
OT  - Retina
OT  - apoptosis
OT  - development
OT  - proliferating cell nuclear antigen
OT  - proliferation
COIS- None.
EDAT- 2017/12/01 00:00
MHDA- 2017/12/01 00:01
PMCR- 2017/12/01
CRDT- 2020/01/23 06:00
PHST- 2017/09/15 00:00 [received]
PHST- 2017/10/24 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2017/12/01 00:00 [pubmed]
PHST- 2017/12/01 00:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2017 Dec 1;10(12):11679-11684. eCollection 2017.