PMID- 31966589
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200126
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 10
IP  - 7
DP  - 2017
TI  - Pathological features of mammary analogue secretory carcinoma of the salivary 
      gland.
PG  - 7460-7465
AB  - The present study aimed to investigate the histopathological and 
      immunohistochemical characteristics of Mammary Analogue Secretory Carcinoma 
      (MASC) of the Salivary Gland. METHODS: Four cases of MASC were diagnosed after 
      microscope images review, immunohistochemsitry (IHC) for Mammaglobin protein, 
      Gata3 protein, S-100 protein, DOG1 protein, and break-apart ETV6 fluorescence in 
      situ hybridization (FISH) in forty salivary gland tumors. RESULTS: We have shown 
      a t(12;15)(p13;q25) ETV6-NTRK3 translocation in all but one case of MASC suitable 
      for analysis. This translocation was not found in any other salivary gland tumor 
      types including acinic cell carcinoma (AciCC, 30 cases) and mucoepidermoid 
      carcinoma (MEC, 6 cases). In IHC, all MASC showed diffuse positivity for 
      Mammaglobin protein, Gata3 protein and S100 protein, as the DOG1 was negative. 
      CONCLUSIONS: MASC is rare tumor and often misdiagnosed as other salivary tumors, 
      but whose specific histopathological, IHC and molecular genetic characteristics 
      can help to identify it. ETV6-NTRK3 gene translocation is easily found in MASC, 
      but may not occur in every case.
CI  - IJCEP Copyright (c) 2017.
FAU - Shi, Ke
AU  - Shi K
AD  - Department of Pathology, The First Affiliated Hospital of Zhengzhou University 
      Zhengzhou, China.
FAU - Lv, Xin-Quan
AU  - Lv XQ
AD  - Department of Pathology, The First Affiliated Hospital of Zhengzhou University 
      Zhengzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20170701
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6965290
OTO - NOTNLM
OT  - ETV6-NTRK3 translocation
OT  - Mammary analogue secretory carcinoma of the salivary gland
OT  - acinic cell carcinoma
OT  - molecular pathology
OT  - mucoepidermoid carcinoma
COIS- None.
EDAT- 2017/07/01 00:00
MHDA- 2017/07/01 00:01
PMCR- 2017/07/01
CRDT- 2020/01/23 06:00
PHST- 2017/02/08 00:00 [received]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2017/07/01 00:00 [pubmed]
PHST- 2017/07/01 00:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2017 Jul 1;10(7):7460-7465. eCollection 2017.