PMID- 31966598
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200126
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 10
IP  - 7
DP  - 2017
TI  - Vasculogenic mimicry and expression of Twist1 and KAI1 correlate with metastasis 
      and prognosis in lung squamous cell carcinoma.
PG  - 7542-7550
AB  - BACKGROUND: Vasculogenic mimicry (VM) is a new blood supply development often 
      seen in highly aggressive cancers and has been considered as a usefully 
      metastatic and prognostic factor for many cancers. Twist1 (a biomarker of 
      epithelial-mesenchymal transition), and KAI1 (a suppressor of tumor metastasis) 
      are both usefully predictive factors for metastasis in many cancers. However, the 
      metastatic and prognostic value of VM, Twist1, or KAI1 in lung squamous cell 
      carcinoma (LSCC) is unclear. In this study, we analyzed associations among VM, 
      Twist1, and KAI1 in LSCC, and their respective associations with 
      clinicopathological parameters and survival in LSCC. CASE PRESENTATION: Positive 
      rates of VM, Twist1, and KAI1 in 157 whole LSCC tissue specimens were detected by 
      immunohistochemistry and histochemical staining. Patient's clinical data were 
      also collected. Levels of VM and Twist1 were significantly higher, and levels of 
      KAI1 were significantly lower, in LSCC tissues than in normal lung tissues. 
      Levels of VM and Twist1 were positively associated with tumor grade, lymph node 
      metastasis (LNM), and tumor-node-metastasis (TNM) stage, and inversely with 
      patients overall survival (OS) time; levels of KAI1 was negatively associated 
      with tumor grade, LNM, and TNM stage, and the KAI1+ subgroup had significantly 
      longer OS time than did the KAI1- subgroup. In multivariate analysis, high VM, or 
      Twist1 levels, TNM stage, size of tumors, and low KAI1 levels were potential to 
      be independent prognostic factors for OS time in patients with LSCC. CONCLUSIONS: 
      VM, and the expression of Twist1 and KAI1 represent promising markers for 
      metastasis and prognosis, and potential therapeutic targets for LSCC.
CI  - IJCEP Copyright (c) 2017.
FAU - Zhou, Lei
AU  - Zhou L
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College 
      Anhui Province, China.
AD  - Department of Pathology, Bengbu Medical College Anhui Province, China.
FAU - Yu, Lan
AU  - Yu L
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College 
      Anhui Province, China.
AD  - Department of Pathology, Bengbu Medical College Anhui Province, China.
FAU - Zhu, Bo
AU  - Zhu B
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College 
      Anhui Province, China.
AD  - Department of Pathology, Bengbu Medical College Anhui Province, China.
FAU - Wu, Shiwu
AU  - Wu S
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College 
      Anhui Province, China.
AD  - Department of Pathology, Bengbu Medical College Anhui Province, China.
FAU - Song, Wenqing
AU  - Song W
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College 
      Anhui Province, China.
AD  - Department of Pathology, Bengbu Medical College Anhui Province, China.
FAU - Gong, Xiaomeng
AU  - Gong X
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College 
      Anhui Province, China.
AD  - Department of Pathology, Bengbu Medical College Anhui Province, China.
FAU - Wang, Danna
AU  - Wang D
AD  - Department of Pathology, The First Affiliated Hospital of Bengbu Medical College 
      Anhui Province, China.
AD  - Department of Pathology, Bengbu Medical College Anhui Province, China.
LA  - eng
PT  - Journal Article
DEP - 20170701
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6965271
OTO - NOTNLM
OT  - KAI1
OT  - Lung squamous cell carcinoma
OT  - Twist1
OT  - VM
OT  - prognosis
COIS- None.
EDAT- 2017/07/01 00:00
MHDA- 2017/07/01 00:01
PMCR- 2017/07/01
CRDT- 2020/01/23 06:00
PHST- 2017/03/21 00:00 [received]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2017/07/01 00:00 [pubmed]
PHST- 2017/07/01 00:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2017 Jul 1;10(7):7542-7550. eCollection 2017.