PMID- 31966633
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200126
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 10
IP  - 7
DP  - 2017
TI  - Increased expression of kidney injury molecule-1 and matrix metalloproteinase-3 
      in severe Plasmodium falciparum malaria with acute kidney injury.
PG  - 7856-7864
AB  - Kidney injury molecule-1 (KIM-1) is a specific histological biomarker for 
      diagnosing early acute kidney injury which is markedly up-regulated in the 
      proximal tubular cells in acute and chronic tubular injury. KIM-1 expression is 
      poorly defined in the renal tubules of malaria patients. This present study aimed 
      to determine KIM-1 expression as a specific biomarker for acute tubular damage 
      and to identify matrix metalloproteinase-3 (MMP-3) as a mediator for KIM-1 
      shedding. Paraffin-embedded kidney tissues from autopsies of malaria patients 
      were obtained from the Department of Tropical Pathology, Faculty of Tropical 
      Medicine, Mahidol University, Thailand. The kidney tissues were divided into 2 
      groups: those with acute kidney injury (AKI) (n = 10 cases) and those with 
      non-AKI (n = 10 cases). Ten normal kidney tissues were used as a control group. 
      The expression of KIM-1 and MMP-3 was examined by immunohistochemical staining. 
      KIM-1 and MMP-3 expressions were strongly expressed in the proximal tubular cells 
      in all kidney tissues from severe Plasmodium falciparum malaria with histological 
      changes showing acute tubular damage. The mean intensity and total score of KIM-1 
      and MMP-3 expressions were significantly increased in proximal tubules of AKI 
      group compared to non-AKI and control groups (all P < 0.001). There was a 
      significant positive correlation of total score of KIM-1 expression and the 
      parameters of kidney function for AKI, including serum creatinine (Cr) and blood 
      urea nitrogen (BUN). In addition, strong positive correlations were found between 
      total score of KIM-1 expression and proximal tubular necrosis and MMP-3 
      expression. The study supports the potential role of KIM-1 as a specific 
      biomarker for renal proximal tubular damage in malarial AKI, and indicates that 
      the process of KIM-1 shedding might be stimulated by MMP-3.
CI  - IJCEP Copyright (c) 2017.
FAU - Punsawad, Chuchard
AU  - Punsawad C
AD  - School of Medicine, Walailak University Nakhon Si Thammarat, Thailand.
AD  - Tropical Diseases and Parasitic Infectious Diseases Research Group, Walailak 
      University Nakhon Si Thammarat, Thailand.
FAU - Viriyavejakul, Parnpen
AU  - Viriyavejakul P
AD  - Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol 
      University Bangkok, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20170701
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6965263
OTO - NOTNLM
OT  - AKI
OT  - KIM-1
OT  - Kidney injury molecule-1
OT  - MMP-3
OT  - Plasmodium falciparum
OT  - acute kidney injury
OT  - malaria
OT  - matrix metalloproteinase-3
COIS- None.
EDAT- 2017/07/01 00:00
MHDA- 2017/07/01 00:01
PMCR- 2017/07/01
CRDT- 2020/01/23 06:00
PHST- 2017/04/28 00:00 [received]
PHST- 2017/06/23 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2017/07/01 00:00 [pubmed]
PHST- 2017/07/01 00:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2017 Jul 1;10(7):7856-7864. eCollection 2017.