PMID- 31966833
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200126
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 10
IP  - 9
DP  - 2017
TI  - Cytokine production of papillary thyroid carcinoma coexisting with Hashimoto's 
      thyroiditis.
PG  - 9567-9574
AB  - In the tumor microenvironment coexisting with Hashimoto's thyroiditis (HT), 
      cytokines secreted by the tumor cells, stroma cells, or immune cells play a 
      critical role in the regulation of tumor growth, invasion, and metastasis. The 
      present study aims to understand cytokine production from cancerous tissues (CT), 
      para-cancerous tissues (PT), and serum in patients with papillary thyroid 
      carcinoma (PTC) with or without accompanying HT. Using a multiplexed human 
      cytokine assay, we found that nine cytokines, including Interleukin-1alpha 
      (IL-1alpha), Interleukin-1beta (IL-1beta), Interleukin-12p70 (IL-12p70), Interleukin-8 
      (IL-8), Interferon-inducible protein-10 (IP-10), Monocyte chemoattractant 
      protein-1 (MCP-1), Macrophage inflammatory protein-1alpha (MIP-1alpha), Macrophage 
      inflammatory protein-1beta (MIP-1beta), and soluble E-selectin (sE-Selectin), showed 
      significantly higher expression in para-cancerous tissues of HT(+)PTC compared 
      with HT(-)PTC (P<0.05). In addition, H&E staining showed immune cell infiltration 
      in PT but not in CT. Moreover para-cancerous tissues of HT(+)PTC patients 
      produced more Interferon-alpha (IFN-alpha) (P=0.048) and Interferon-gamma (IFN-gamma) 
      (P=0.004) compared with cancerous tissues, and production of Intercellular cell 
      adhesion molecule-1 (ICAM-1) was significantly higher in CT than PT both in 
      HT(+)PTC (P=0.001) and HT(-)PTC (P=0.012) patients. To conclude, autoimmune HT 
      was found to affect the cytokine profiles in patients with PTC by stimulating 
      secretion of Th1-type cytokines and chemokines, but further studies are needed to 
      determine the significance of these findings and to reveal the exact mechanism of 
      the interactions between chemokines and cytokines in the pathogenesis of HT and 
      PTC.
CI  - IJCEP Copyright (c) 2017.
FAU - Shi, Liuhong
AU  - Shi L
AD  - Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of 
      Zhejiang University, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang 
      University Hangzhou, Zhejiang Province, China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of 
      Zhejiang University, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang 
      University Hangzhou, Zhejiang Province, China.
FAU - Wang, Jianbiao
AU  - Wang J
AD  - Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of 
      Zhejiang University, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang 
      University Hangzhou, Zhejiang Province, China.
FAU - Li, Feibo
AU  - Li F
AD  - Second Department of General Surgery, Zhejiang Putuo Hospital Zhoushan, Zhejiang 
      Province, China.
FAU - Xie, Lei
AU  - Xie L
AD  - Department of Head and Neck Surgery, Institute of Micro-Invasive Surgery of 
      Zhejiang University, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang 
      University Hangzhou, Zhejiang Province, China.
LA  - eng
PT  - Journal Article
DEP - 20170901
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
PMC - PMC6965928
OTO - NOTNLM
OT  - Hashimoto's thyroiditis
OT  - chemokine
OT  - cytokine
OT  - papillary thyroid carcinoma
COIS- None.
EDAT- 2017/09/01 00:00
MHDA- 2017/09/01 00:01
PMCR- 2017/09/01
CRDT- 2020/01/23 06:00
PHST- 2017/05/31 00:00 [received]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2017/09/01 00:00 [pubmed]
PHST- 2017/09/01 00:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2017 Sep 1;10(9):9567-9574. eCollection 2017.