PMID- 31966992
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220412
IS  - 2376-0605 (Electronic)
IS  - 2376-0605 (Linking)
VI  - 5
IP  - 1
DP  - 2019 Jan-Feb
TI  - CO-EXISTENCE OF PRIMARY HYPERPARATHYROIDISM DUE TO MULTIPLE ENDOCRINE NEOPLASIA 1 
      IN A HYPERCALCEMIC PATIENT WITH GRAVES DISEASE.
PG  - e13-e15
LID - 10.4158/ACCR-2018-0217 [doi]
AB  - OBJECTIVE: Hypercalcemia in a patient with Graves disease can occur in up to 22% 
      of cases. The mechanism is thought to be increased bone resorption. There are 
      more rare causes of hypercalcemia in these patients with hyperthyroidism, such as 
      hyperparathyroidism, which occurs in less than 1% of patients. We describe a rare 
      occurrence of primary hyperparathyroidism due to multiple endocrine neoplasia 
      type 1 (MEN 1) in a Graves disease patient presenting with hyperthyroidism and 
      hypercalcemia. METHODS: The patient initially presented with a 3-week history of 
      nausea, vomiting, and abdominal pain. She also had an 8-week history of a 
      12-pound weight loss. She was diagnosed with hyperthyroidism secondary to Graves 
      disease and was noted to have concurrent hypercalcemia. She was diagnosed with 
      primary hyperparathyroidism. The patient underwent subtotal thyroidectomy and 
      total parathyroidectomy with forearm autotransplantation. Subsequent genetic 
      testing confirmed the diagnosis of MEN 1. RESULTS: A review of the literature was 
      conducted to identify previous studies pertaining to concurrent hypercalcemia in 
      hyperthyroid patients, focusing on reports related to their diagnosis and 
      management. CONCLUSION: Co-existing primary hyperparathyroidism due to MEN 1, 
      although rare, should be considered in a patient with hyperthyroidism and 
      hypercalcemia. A thorough evaluation is necessary to avoid a delay in the correct 
      diagnosis and treatment of the underlying conditions. Clinicians should be aware 
      of the rare occurrence of primary hyperparathyroidism due to MEN 1 in a Graves 
      disease patient presenting with hyperthyroidism and hypercalcemia.
CI  - Copyright (c) 2019 AACE.
FAU - Bhat, Shalini
AU  - Bhat S
FAU - Davis, Susan
AU  - Davis S
LA  - eng
PT  - Case Reports
DEP - 20190130
PL  - United States
TA  - AACE Clin Case Rep
JT  - AACE clinical case reports
JID - 101670593
PMC - PMC6876967
COIS- DISCLOSURE The authors have no multiplicity of interest to disclose.
EDAT- 2020/01/23 06:00
MHDA- 2020/01/23 06:01
PMCR- 2019/01/30
CRDT- 2020/01/23 06:00
PHST- 2018/05/08 00:00 [received]
PHST- 2018/07/23 00:00 [accepted]
PHST- 2020/01/23 06:00 [entrez]
PHST- 2020/01/23 06:00 [pubmed]
PHST- 2020/01/23 06:01 [medline]
PHST- 2019/01/30 00:00 [pmc-release]
AID - 10.4158/ACCR-2018-0217 [doi]
PST - epublish
SO  - AACE Clin Case Rep. 2019 Jan 30;5(1):e13-e15. doi: 10.4158/ACCR-2018-0217. 
      eCollection 2019 Jan-Feb.