PMID- 31968410
OWN - NLM
STAT- MEDLINE
DCOM- 20210531
LR  - 20210531
IS  - 1533-4899 (Electronic)
IS  - 1533-4880 (Linking)
VI  - 20
IP  - 7
DP  - 2020 Jul 1
TI  - Ceria-Doped Titania Nanoparticles as Drug Delivery System.
PG  - 3971-3980
LID - 10.1166/jnn.2020.17206 [doi]
AB  - The development of new devices at the nanoscale level, as therapeutic support in 
      medical practice, has facilitated the development of drug delivery systems (DDSs) 
      based on nanoparticles. This enables the transport of an effective dose of 
      therapeutic agents to target cells or tissues, with no collateral damage to 
      healthy cells. Owing to their unique properties, nanoparticles doped with rare 
      earths have demonstrated the potential of being used as a DDS of drug molecules 
      to target cells or tissues. In the present work, ceria-doped titania 
      nanoparticles (CeO(2)/TiO(2)NPs) were used to form the DNR-CeO(2)/TiO(2)NPs complex as a 
      DDS of daunorubicin (DNR), which was tested in a B-lymphocyte cell culture. The 
      CeO(2)/TiO(2)NPs were synthesized via the sol-gel process in a microemulsion of 
      reverse micelle. In general, the results indicated that the nanoparticles 
      presented good biocompatibility and load efficiency superior to that reported in 
      other investigations for pure titania nanoparticles, suggesting that the 
      CeO(2)/TiO(2)NPs increased intracellular accumulation of the drug. These results 
      indicate that a delivery strategy using CeO(2)/TiO(2)NPs is a promising approach in 
      the medical field, particularly in anticancer therapies.
FAU - Torres-Romero, A
AU  - Torres-Romero A
AD  - Instituto de Investigacion en Metalurgia y Materiales, Universidad Michoacana de 
      San Nicolas de Hidalgo, Morelia 58060, Mexico.
FAU - Cajero-Juarez, M
AU  - Cajero-Juarez M
AD  - Instituto de Investigaciones Agropecuarias y Forestales, Universidad Michoacana 
      de San Nicolas de Hidalgo, Morelia 58100, Mexico.
FAU - Nunez-Anita, R E
AU  - Nunez-Anita RE
AD  - Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San 
      Nicolas de Hidalgo, Morelia 58100, Mexico.
FAU - Contreras-Garcia, M E
AU  - Contreras-Garcia ME
AD  - Instituto de Investigacion en Metalurgia y Materiales, Universidad Michoacana de 
      San Nicolas de Hidalgo, Morelia 58060, Mexico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nanosci Nanotechnol
JT  - Journal of nanoscience and nanotechnology
JID - 101088195
RN  - 15FIX9V2JP (titanium dioxide)
RN  - D1JT611TNE (Titanium)
RN  - ZS7284E0ZP (Daunorubicin)
SB  - IM
MH  - Daunorubicin
MH  - *Drug Delivery Systems
MH  - *Nanoparticles
MH  - Titanium
EDAT- 2020/01/24 06:00
MHDA- 2021/06/01 06:00
CRDT- 2020/01/24 06:00
PHST- 2020/01/24 06:00 [entrez]
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2021/06/01 06:00 [medline]
AID - 10.1166/jnn.2020.17206 [doi]
PST - ppublish
SO  - J Nanosci Nanotechnol. 2020 Jul 1;20(7):3971-3980. doi: 10.1166/jnn.2020.17206.