PMID- 31968595
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20201116
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Jan 20
TI  - Impact of Enhanced Recovery after Surgery with Preoperative Whey Protein-Infused 
      Carbohydrate Loading and Postoperative Early Oral Feeding among Surgical 
      Gynecologic Cancer Patients: An Open-Labelled Randomized Controlled Trial.
LID - 10.3390/nu12010264 [doi]
LID - 264
AB  - Enhanced Recovery after Surgery (ERAS) with sole carbohydrate (CHO) loading and 
      postoperative early oral feeding (POEOF) shortened the length of postoperative 
      (PO) hospital stays (LPOHS) without increasing complications. This study aimed to 
      examine the impact of ERAS with preoperative whey protein-infused CHO loading and 
      POEOF among surgical gynecologic cancer (GC) patients. There were 62 subjects in 
      the intervention group (CHO-P), which received preoperative whey protein-infused 
      CHO loading and POEOF; and 56 subjects formed the control group (CO), which was 
      given usual care. The mean age was 49.5 +/- 12.2 years (CHO-P) and 51.2 +/- 11.9 
      years (CO). The trial found significant positive results which included shorter 
      LPOHS (78.13 +/- 33.05 vs. 99.49 +/- 22.54 h); a lower readmission rate within one 
      month PO (6% vs. 16%); lower weight loss (-0.3 +/- 2.3 kg vs. -2.1 +/- 2.3 kg); a 
      lower C-reactive protein-albumin ratio (0.3 +/- 1.2 vs. 1.1 +/- 2.6); preserved 
      muscle mass (0.4 +/- 1.7 kg vs. -0.7 +/- 2.6 kg); and better handgrip strength (0.6 +/- 
      4.3 kg vs. -1.9 +/- 4.7 kg) among CHO-P as compared with CO. However, there was no 
      significant difference in mid-upper arm circumference and serum albumin level 
      upon discharge. ERAS with preoperative whey protein-infused CHO loading and POEOF 
      assured better PO outcomes.
FAU - Yi, Ho Chiou
AU  - Yi HC
AD  - Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Seri Kembangan 43400, Malaysia.
AD  - Department of Dietetics and Food Service, National Cancer Institute, Ministry of 
      Health, 4, Jalan P7, Presint 7, Putrajaya 62250, Malaysia.
FAU - Ibrahim, Zuriati
AU  - Ibrahim Z
AUID- ORCID: 0000-0001-6210-0443
AD  - Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Seri Kembangan 43400, Malaysia.
FAU - Abu Zaid, Zalina
AU  - Abu Zaid Z
AD  - Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Seri Kembangan 43400, Malaysia.
FAU - Mat Daud, Zulfitri 'Azuan
AU  - Mat Daud Z'
AUID- ORCID: 0000-0002-4017-107X
AD  - Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Seri Kembangan 43400, Malaysia.
FAU - Md Yusop, Nor Baizura
AU  - Md Yusop NB
AD  - Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Seri Kembangan 43400, Malaysia.
FAU - Omar, Jamil
AU  - Omar J
AD  - Department of Surgical Oncology, National Cancer Institute, Ministry of Health, 
      4, Jalan P7, Presint 7, Putrajaya 62250, Malaysia.
FAU - Mohd Abas, Mohd Norazam
AU  - Mohd Abas MN
AD  - Department of Surgical Oncology, National Cancer Institute, Ministry of Health, 
      4, Jalan P7, Presint 7, Putrajaya 62250, Malaysia.
FAU - Abdul Rahman, Zuwariah
AU  - Abdul Rahman Z
AD  - Department of Dietetics and Food Service, National Cancer Institute, Ministry of 
      Health, 4, Jalan P7, Presint 7, Putrajaya 62250, Malaysia.
FAU - Jamhuri, Norshariza
AU  - Jamhuri N
AD  - Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, 
      Universiti Putra Malaysia, Seri Kembangan 43400, Malaysia.
AD  - Department of Dietetics and Food Service, National Cancer Institute, Ministry of 
      Health, 4, Jalan P7, Presint 7, Putrajaya 62250, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200120
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Adult
MH  - Body Composition
MH  - *Diet, Carbohydrate Loading/adverse effects
MH  - Dietary Carbohydrates/*administration & dosage/adverse effects
MH  - *Eating
MH  - *Enhanced Recovery After Surgery
MH  - Female
MH  - *Gynecologic Surgical Procedures/adverse effects
MH  - Hand Strength
MH  - Humans
MH  - Length of Stay
MH  - Malaysia
MH  - Middle Aged
MH  - Nutritional Status
MH  - Recovery of Function
MH  - Time Factors
MH  - Treatment Outcome
MH  - Whey Proteins/*administration & dosage/adverse effects
PMC - PMC7019504
OTO - NOTNLM
OT  - enhanced recovery after surgery
OT  - gynecologic cancer
OT  - whey protein carbohydrate loading
COIS- The authors declare no conflict of interest.
EDAT- 2020/01/24 06:00
MHDA- 2020/11/18 06:00
PMCR- 2020/01/01
CRDT- 2020/01/24 06:00
PHST- 2019/11/27 00:00 [received]
PHST- 2019/12/19 00:00 [revised]
PHST- 2019/12/22 00:00 [accepted]
PHST- 2020/01/24 06:00 [entrez]
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - nu12010264 [pii]
AID - nutrients-12-00264 [pii]
AID - 10.3390/nu12010264 [doi]
PST - epublish
SO  - Nutrients. 2020 Jan 20;12(1):264. doi: 10.3390/nu12010264.