PMID- 31969529
OWN - NLM
STAT- MEDLINE
DCOM- 20210416
LR  - 20221207
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 67
IP  - 4
DP  - 2020 Apr 28
TI  - Risk factors during the early postpartum period for type 2 diabetes mellitus in 
      women with gestational diabetes.
PG  - 427-437
LID - 10.1507/endocrj.EJ19-0367 [doi]
AB  - For women with gestational diabetes mellitus (GDM), the evaluation of glucose 
      tolerance (GT) in the early postpartum period is universally recommended. 
      Nevertheless, few studies have evaluated the risk factors for T2DM on the basis 
      of GT data obtained during the early postpartum period. We aimed to identify the 
      risk factors for type 2 diabetes mellitus (T2DM) by evaluating GT in the first 12 
      weeks postpartum (12wPP) in women with GDM and to categorize the risk using a 
      combination of the principal risk factors. This retrospective multicenter 
      observational study included 399 East Asian women with GDM who underwent a 75-g 
      oral glucose tolerance test (OGTT) within 12wPP, which was repeated annually or 
      biennially and used to identify the postpartum development of T2DM. Forty-three 
      women (10.8%) developed T2DM during a median follow-up period of 789 +/- 477 days. 
      The independent risk factors for T2DM were pre-pregnancy obesity (BMI >/=25 
      kg/m(2)), early postpartum impairment in glucose tolerance (IGT), and an early 
      postpartum glycated hemoglobin (HbA1c) >/=5.7%. The odds ratios (95% confidence 
      intervals) for T2DM were 3.2 (1.3-7.8) in women with either early postpartum IGT 
      or pre-pregnancy obesity, 9.2 (3.0-28.3) in those with early postpartum IGT, 
      pre-pregnancy obesity, and HbA1c <5.7%, and 51.4 (16.1-163.9) in those with early 
      postpartum IGT, pre-pregnancy obesity, and HbA1c >/=5.7%, compared with those 
      without obesity or IGT. T2DM risk in East Asian women with GDM should be 
      stratified according to pre-pregnancy obesity and early postpartum IGT, and these 
      patients should be followed up and receive appropriate care for their risk 
      category.
FAU - Kawasaki, Maki
AU  - Kawasaki M
AD  - Department of Health Policy, National Center for Child Health and Development, 
      Tokyo 157-0074, Japan.
AD  - Department of Molecular Endocrinology and Metabolism, Graduate School of Medical 
      and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
FAU - Arata, Naoko
AU  - Arata N
AD  - Division of Maternal Medicine, Center for Maternal-Fetal, Neonatal, and 
      Reproductive Medicine, National Center for Child Health and Development, Tokyo 
      157-0074, Japan.
FAU - Sakamoto, Naoko
AU  - Sakamoto N
AD  - Department of Epidemiologic Research, Faculty of Nursing, Toho University, Tokyo 
      143-8540, Japan.
FAU - Osamura, Anna
AU  - Osamura A
AD  - Division of Diabetes, Metabolism and Endocrinology, Department of Medicine, Showa 
      University School of Medicine, Tokyo 142-8666, Japan.
FAU - Sato, Siori
AU  - Sato S
AD  - Division of Maternal Medicine, Center for Maternal-Fetal, Neonatal, and 
      Reproductive Medicine, National Center for Child Health and Development, Tokyo 
      157-0074, Japan.
FAU - Ogawa, Yoshihiro
AU  - Ogawa Y
AD  - Department of Molecular and Cellular Metabolism, Graduate School of Medical and 
      Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.
AD  - Department of Medicine and Bioregulatory Science, Graduate School of Medical 
      Sciences, Kyushu University, Fukuoka 812-8582, Japan.
FAU - Yasuhi, Ichiro
AU  - Yasuhi I
AD  - Department of Obstetrics and Gynecology, National Hospital Organization Nagasaki 
      Medical Center, Omura, Nagasaki 856-8562, Japan.
FAU - Waguri, Masako
AU  - Waguri M
AD  - Department of Obstetric Medicine, Osaka Women's and Children's Hospital, Izumi, 
      Osaka 594-1101, Japan.
FAU - Hiramatsu, Yuji
AU  - Hiramatsu Y
AD  - Okayama City General Medical Center, Okayama 700-0962, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
DEP - 20200121
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/*diagnosis/*epidemiology
MH  - Diabetes, Gestational/*physiopathology
MH  - Female
MH  - Glucose Intolerance/physiopathology
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Japan
MH  - Obesity/complications
MH  - Odds Ratio
MH  - *Postpartum Period
MH  - Pregnancy
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Early postpartum period
OT  - Gestational diabetes mellitus
OT  - Oral glucose tolerance test
OT  - Prediction
OT  - Type 2 diabetes mellitus
EDAT- 2020/01/24 06:00
MHDA- 2021/04/17 06:00
CRDT- 2020/01/24 06:00
PHST- 2020/01/24 06:00 [pubmed]
PHST- 2021/04/17 06:00 [medline]
PHST- 2020/01/24 06:00 [entrez]
AID - 10.1507/endocrj.EJ19-0367 [doi]
PST - ppublish
SO  - Endocr J. 2020 Apr 28;67(4):427-437. doi: 10.1507/endocrj.EJ19-0367. Epub 2020 
      Jan 21.